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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia;  Liu, Ming
收藏  |  浏览/下载：114/0  |  提交时间：2024/04/07
Acquired resistance  Cancer  NSCLC  JC-010a  SHP2  
EGPI-1, a novel eIF4E/eIF4G interaction inhibitor, inhibits lung cancer cell growth and angiogenesis through Ras/MNK/ERK/eIF4E signaling pathway 期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2022, 卷号: 352, 页码: 10
作者:  Qi, Xueju;  Zhang, Shuna;  Chen, Zekun;  Wang, Lijun;  Zhu, Wenyong;  Yin, Chuanjin;  Fan, Junting;  Wu, Xiaochen;  Wang, Jing;  Guo, Chuanlong
Adobe PDF(10635Kb)  |  收藏  |  浏览/下载：224/0  |  提交时间：2022/07/18
Human lung cancer  eIF4E  EGPI-1  Anticancer  Angiogenesis  
Novel poly (ADP-ribose) polymerases inhibitor DHC-1 exhibits in vitro and in vivo anticancer activity on BRCA-deficient pancreatic cancer cells 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2021, 卷号: 147, 页码: 10
作者:  Wu, Xiaochen;  Li, Qiqi;  Zhang, Fan;  Wang, Lijun;  Wang, Jun;  Fan, Junting;  Di, Guohu;  Guo, Chuanlong
Adobe PDF(8144Kb)  |  收藏  |  浏览/下载：252/0  |  提交时间：2021/04/21
PARP inhibitor  BRCA  Pancreatic cancer  
Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights 期刊论文
CELLULAR AND MOLECULAR BIOLOGY, 2021, 卷号: 67, 期号: 2, 页码: 178-186
作者:  Farooqi, Ammad Ahmad;  Tahir, Fatima;  Fakhar, Maham;  Butt, Ghazala;  Pimentel, Tatiana Colombo;  Wu, Ning;  Yulaevna, Ishmuratova Margarita;  Attar, Rukset
收藏  |  浏览/下载：153/0  |  提交时间：2022/04/12
Cancer  Apoptosis  Signaling  Xenografted mice  
The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review 期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021, 卷号: 21, 期号: 7, 页码: 803-815
作者:  Zhang, Jiajia;  Wu, Ning;  Shi, Dayong
Adobe PDF(1363Kb)  |  收藏  |  浏览/下载：414/0  |  提交时间：2021/05/11
Signaling pathway  mammalian target of rapamycin  protein tyrosine phosphatase 1b  dipeptidase 4  cancer  diabetes  pharmacology  target compounds  
Novel eIF4E/eIF4G protein-protein interaction inhibitors DDH-1 exhibits anti-cancer activity in vivo and in vitro 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 160, 页码: 496-505
作者:  Wang, Jun;  Wang, Lijun;  Zhang, Shuhong;  Fan, Junting;  Yang, Hui;  Li, Qiqi;  Guo, Chuanlong
Adobe PDF(3920Kb)  |  收藏  |  浏览/下载：307/0  |  提交时间：2020/10/26
eIF4E/eIF4G  Human lung cancer  Apoptosis  DNA damage  ROS  
The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21, 期号: 3, 页码: 15
作者:  Zhang, Jiajia;  Dai, Jiajia;  Zheng, Qingxuan;  Guo, Shuju;  Yu, Yanyan;  Hu, Wenpeng;  Gao, Yanan;  Shi, Dayong
Adobe PDF(2858Kb)  |  收藏  |  浏览/下载：267/0  |  提交时间：2020/09/23
triple negative breast cancer  MDA-MB-231 cells  fluoro-thiazolylhydrazone  MAPK pathway  phosphorylated p44/42 MAPK (ERK1/2)  phosphorylated c-Jun N-terminal kinase (p-JNK)  apoptosis  
The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer 期刊论文
CANCERS, 2019, 卷号: 11, 期号: 9, 页码: 26
作者:  Wang, Man;  Jiang, Shuai;  Zhang, Yinfeng;  Li, Peifeng;  Wang, Kun
Adobe PDF(2571Kb)  |  收藏  |  浏览/下载：327/0  |  提交时间：2020/01/03
pyroptosis  cancer  inflammasome  gasdermin  pro-inflammatory cytokine  cancer pathogenesis  therapeutic utility  
Noncoding RNAs as Molecular Targets of Resveratrol Underlying Its Anticancer Effects 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 17, 页码: 4709-4719
作者:  Wang, Man;  Jiang, Shuai;  Yu, Fei;  Zhou, Li;  Wang, Kun
Adobe PDF(1080Kb)  |  收藏  |  浏览/下载：346/0  |  提交时间：2019/08/28
resveratrol  cancer  miRNA  incRNA  anticancer effect  
Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2019, 卷号: 15, 期号: 6, 页码: 1200-1214
作者:  Wang, Man;  Jiang, Shuai;  Zhou, Li;  Yu, Fei;  Ding, Han;  Li, Peifeng;  Zhou, Meng;  Wang, Kun
收藏  |  浏览/下载：295/0  |  提交时间：2019/08/29
curcumin  cancer  signaling pathways  miRNAs