The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review

doi:10.2174/1389557520666201113110406

	The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review
	Zhang, Jiajia 1,2,4; Wu, Ning 1,2; Shi, Dayong 1,2,3,4
	2021
发表期刊	MINI-REVIEWS IN MEDICINAL CHEMISTRY
ISSN	1389-5575
卷号	21 期号:7 页码:803-815
通讯作者	Wu, Ning([email protected]) ; Shi, Dayong([email protected])
摘要	Background: The mammalian target of rapamycin (mTOR), protein tyrosine phosphatase 1b (PTP1B) and dipeptidase 4 (DPP4) signaling pathways regulate eukaryotic cell proliferation and metabolism. Previous researches described different transduction mechanisms in the progression of cancer and diabetes. Methodology: We reviewed recent advances in the signal transduction pathways of mTOR, PTP1B and DPP4 regulation and determined the crosstalk and common pathway in diabetes and cancer. Results: We showed that according to numerous past studies, the proteins participate in the signaling networks for both diseases. Conclusion: There are common pathways and specific proteins involved in diabetes and cancer. This article demonstrates and explains the potential mechanisms of association and future prospects for targeting these proteins in pharmacological studies.
关键词	Signaling pathway mammalian target of rapamycin protein tyrosine phosphatase 1b dipeptidase 4 cancer diabetes pharmacology target compounds
DOI	10.2174/1389557520666201113110406
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81803375]; National Natural Science Foundation of China[81773586]; National Natural Science Foundation of China[81903354]; National Natural Science Foundation of China[81872906]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000631285400002
出版者	BENTHAM SCIENCE PUBL LTD
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/170279
专题	中国科学院海洋大科学研究中心
通讯作者	Wu, Ning; Shi, Dayong
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China 2.Lab Marine Drugs & Bioprod Qingdao Natl Lab Marin, Qingdao, Shandong, Peoples R China 3.Shandong Univ, State Key Lab Microbial Technol, Jinan, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Zhang, Jiajia,Wu, Ning,Shi, Dayong. The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2021,21(7):803-815.
APA	Zhang, Jiajia,Wu, Ning,&Shi, Dayong.(2021).The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review.MINI-REVIEWS IN MEDICINAL CHEMISTRY,21(7),803-815.
MLA	Zhang, Jiajia,et al."The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review".MINI-REVIEWS IN MEDICINAL CHEMISTRY 21.7(2021):803-815.

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