The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer

doi:10.3390/cancers11091313

IOCAS-IR

	The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer
	Wang, Man 1; Jiang, Shuai 2; Zhang, Yinfeng 1; Li, Peifeng 1; Wang, Kun1
	2019-09-01
发表期刊	CANCERS
卷号	11 期号:9 页码:26
通讯作者	Wang, Man([email protected]) ; Wang, Kun([email protected])
摘要	Cancer is a category of diseases involving abnormal cell growth with the potential to invade other parts of the body. Chemotherapy is the most widely used first-line treatment for multiple forms of cancer. Chemotherapeutic agents act via targeting the cellular apoptotic pathway. However, cancer cells usually acquire chemoresistance, leading to poor outcomes in cancer patients. For that reason, it is imperative to discover other cell death pathways for improved cancer intervention. Pyroptosis is a new form of programmed cell death that commonly occurs upon pathogen invasion. Pyroptosis is marked by cell swelling and plasma membrane rupture, which results in the release of cytosolic contents into the extracellular space. Currently, pyroptosis is proposed to be an alternative mode of cell death in cancer treatment. Accumulating evidence shows that the key components of pyroptotic cell death pathways, including inflammasomes, gasdermins and pro-inflammatory cytokines, are involved in the initiation and progression of cancer. Interfering with pyroptotic cell death pathways may represent a promising therapeutic option for cancer management. In this review, we describe the current knowledge regarding the biological significance of pyroptotic cell death pathways in cancer pathogenesis and also discuss their potential therapeutic utility.
关键词	pyroptosis cancer inflammasome gasdermin pro-inflammatory cytokine cancer pathogenesis therapeutic utility
DOI	10.3390/cancers11091313
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81701991]###731; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch]###732; National Natural Science Foundation of China[81701991]; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000489719000098
出版者	MDPI
引用统计	被引频次：47[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/163408
专题	中国科学院海洋研究所
通讯作者	Wang, Man; Wang, Kun
作者单位	1.Qingdao Univ, Inst Translat Med, Med Coll, Dengzhou Rd 38, Qingdao 266021, Shandong, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Man,Jiang, Shuai,Zhang, Yinfeng,et al. The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer[J]. CANCERS,2019,11(9):26.
APA	Wang, Man,Jiang, Shuai,Zhang, Yinfeng,Li, Peifeng,&Wang, Kun.(2019).The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer.CANCERS,11(9),26.
MLA	Wang, Man,et al."The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer".CANCERS 11.9(2019):26.

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