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Therapeutic potential of enzymatically extracted eumelanin from squid ink in type 2 diabetes mellitus ICR mice: Multifaceted intervention against hyperglycemia, oxidative stress and depression 期刊论文
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2023, 页码: 15
作者:  Song, Wen;  Xing, Ronge;  Yang, Haoyue;  Liu, Song;  Yu, Huahua;  Li, Pengcheng
收藏  |  浏览/下载：210/0  |  提交时间：2023/11/30
type 2 diabetes mellitus (T2DM)  eumelanin  hypoglycemic activity  antioxidant activity  antidepressant activity  
Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 13
作者:  Jiang, Bo;  Luo, Jiao;  Guo, Shuju;  Wang, Lijun
Adobe PDF(8153Kb)  |  收藏  |  浏览/下载：254/0  |  提交时间：2021/05/11
Type 2 diabetes mellitus  Protein tyrosine phosphatase 1B inhibitors  Thiazolidinedione  Insulin signaling  Anti-diabetic activities  
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2 ',3,3 '-Tetrabromo-4,4 ',5,5 '-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice 期刊论文
MOLECULAR PHARMACEUTICS, 2019, 卷号: 16, 期号: 5, 页码: 1839-1850
作者:  Li, Chao;  Luo, Jiao;  Guo, Shuju;  Jia, Xiaoling;  Guo, Chuanlong;  Li, Xiangqian;  Xu, Qi;  Shi, Dayong
收藏  |  浏览/下载：445/0  |  提交时间：2019/08/28
type 2 diabetes mellitus  protein tyrosine phosphatase 1B  insulin resistance  hypoglycemic activity  dyslipidemia  
The Hot and Potential Targets of Type 2 Diabetes Mellitus Treatment in Recent Decade 期刊论文
CURRENT DRUG TARGETS, 2018, 卷号: 19, 期号: 1, 页码: 55-69
作者:  Xu, Qi;  Wang, Lijun;  Luo, Jiao;  Shi, Dayong
Adobe PDF(2267Kb)  |  收藏  |  浏览/下载：255/0  |  提交时间：2018/04/02
Type 2 Diabetes Mellitus  Insulin Resistance  Insulin Secretion  Targets  Mechanism  Drugs  
Small Molecules as Potent Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors Documented in Patents from 2009 to 2013 期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2015, 卷号: 15, 期号: 2, 页码: 104-122
作者:  Wang, Li-Jun;  Jiang, Bo;  Wu, Ning;  Wang, Shuai-Yu;  Shi, Da-Yong
Adobe PDF(461Kb)  |  收藏  |  浏览/下载：307/0  |  提交时间：2015/06/15
Chemical Modification  Diabetes Mellitus  Natural Products  Patents  Ptp1b Inhibitors  Synthesized Compounds  Type 2 Diabetes Mellitus (2-dm)  
Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 64, 页码: 129-136
作者:  Jiang, Bo;  Guo, Shuju;  Shi, Dayong;  Guo, Chao;  Wang, Tao;  Shi, DY
Adobe PDF(1213Kb)  |  收藏  |  浏览/下载：387/1  |  提交时间：2014/07/17
Type 2 Diabetes Mellitus  Protein Tyrosine Phosphatase 1b  Bromophenol  Anti-diabetic Activities  
Bromophenols from marine algae with potential anti-diabetic activities 期刊论文
JOURNAL OF OCEAN UNIVERSITY OF CHINA, 2012, 卷号: 11, 期号: 4, 页码: 533-538
作者:  Lin Xiukun;  Liu Ming;  Lin, XK (reprint author), Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China.
Adobe PDF(402Kb)  |  收藏  |  浏览/下载：248/0  |  提交时间：2013/09/24
Bromophenols  Marine Algae  Type 2 Diabetes Mellitus  
Design, Synthesis, and Biological Evaluation of Bromophenol Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors 期刊论文
ARCHIV DER PHARMAZIE, 2012, 卷号: 345, 期号: 6, 页码: 444-453
作者:  Jiang, Bo;  Shi, Dayong;  Cui, Yongchao;  Guo, Shuju;  Shi, DY (reprint author), Chinese Acad Sci, R&D Ctr Marine Biotechnol, Inst Oceanol, Qingdao, Peoples R China.
Adobe PDF(473Kb)  |  收藏  |  浏览/下载：330/1  |  提交时间：2013/09/24
Bromophenol  Protein Tyrosine Phosphatase 1b Inhibitor  Structure-activity Relationship  Type 2 Diabetes Mellitus