| Small Molecules as Potent Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors Documented in Patents from 2009 to 2013 | |
| Wang, Li-Jun; Jiang, Bo; Wu, Ning; Wang, Shuai-Yu; Shi, Da-Yong | |
| 2015 | |
| 发表期刊 | MINI-REVIEWS IN MEDICINAL CHEMISTRY
 |
| 卷号 | 15期号:2页码:104-122 |
| 文章类型 | Review |
| 摘要 | Diabetes mellitus, including type 1 and type 2 diabetes mellitus (2-DM) are the main threats to human health in the worldwide. Protein tyrosine phosphatase 1B (PTP1B) is a promising molecular level legitimate therapeutic target in the effective management of 2-DM. For the search of potent PTP1B inhibitors, much investigation has revealed a large number of small-molecule compounds obtained from natural sources or prepared by synthesis/semi-synthesis with various skeletons and promising anti-PTP1B activities in the treatment of 2-DM. Although some reviews on the development of PTP1B inhibitors have been published, they were mainly concentrated on the results reported in journal articles. In this review, we will provide an overview of the developments of the potent PTP1B inhibitors claimed in recent patents during the past five years (2009-2013) with their structural features and biological features, as well as the structure-activity relationships (SARs) and strategies for finding potent and specific PTP1B inhibitors. This paper will provide valuable information for understanding the current anti-PTP1B investigation and developing potent PTP1B inhibitors as treating 2-DM drugs. |
| 关键词 | Chemical Modification Diabetes Mellitus Natural Products Patents Ptp1b Inhibitors Synthesized Compounds Type 2 Diabetes Mellitus (2-dm) |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351925600003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/25460 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Li-Jun,Jiang, Bo,Wu, Ning,et al. Small Molecules as Potent Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors Documented in Patents from 2009 to 2013[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2015,15(2):104-122. |
| APA | Wang, Li-Jun,Jiang, Bo,Wu, Ning,Wang, Shuai-Yu,&Shi, Da-Yong.(2015).Small Molecules as Potent Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors Documented in Patents from 2009 to 2013.MINI-REVIEWS IN MEDICINAL CHEMISTRY,15(2),104-122. |
| MLA | Wang, Li-Jun,et al."Small Molecules as Potent Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors Documented in Patents from 2009 to 2013".MINI-REVIEWS IN MEDICINAL CHEMISTRY 15.2(2015):104-122. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Small Molecules as P（461KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
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