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IOCAS-IR

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Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:  Luo, Jiao;  Zheng, Meiling;  Jiang, Bo;  Li, Chao;  Guo, Shuju;  Wang, Lijun;  Li, Xiangqian;  Yu, Rilei;  Shi, Dayong
Adobe PDF(42653Kb)  |  收藏  |  浏览/下载：421/0  |  提交时间：2020/09/29
bromophenol  PTP1B inhibitor  selectivity  cell permeability  oral bioavailability  
CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes 期刊论文
MARINE DRUGS, 2020, 卷号: 18, 期号: 5, 页码: 13
作者:  Luo, Jiao;  Hou, Yufei;  Xie, Mengyue;  Ma, Wanli;  Shi, Dayong;  Jiang, Bo
Adobe PDF(2455Kb)  |  收藏  |  浏览/下载：350/0  |  提交时间：2020/09/25
CYC31  PTP1B inhibitor  insulin resistance  fatty acid oxidization  
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 178-185
作者:  Li, Xiangqian;  Xu, Qi;  Li, Chao;  Luo, Jiao;  Li, Xiuxue;  Wang, Lijun;  Jiang, Bo;  Shi, Dayong
Adobe PDF(2321Kb)  |  收藏  |  浏览/下载：242/0  |  提交时间：2019/05/15
Anti-diabetic  PTP1B inhibitor  Selectivity  BKS db mice  Toxicity  
The design strategy of selective PTP1B inhibitors over TCPTP 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 16, 页码: 3343-3352
作者:  Li, XiangQian;  Wang, LiJun;  Shi, DaYong
Adobe PDF(2312Kb)  |  收藏  |  浏览/下载：231/1  |  提交时间：2016/12/05
Selectivity  Ptp1b Inhibitor  Tcptp  Diabetes  Design Strategy  
Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor 期刊论文
CHINESE CHEMICAL LETTERS, 2008, 卷号: 19, 期号: 11, 页码: 1290-1292
作者:  Li, Jing;  Guo, Shu Ju;  Su, Hua;  Han, Li Jun;  shi, Da Yong
Adobe PDF(181Kb)  |  收藏  |  浏览/下载：371/0  |  提交时间：2010/12/24
Bromophenol  Ptp1b Inhibitor  Bis-(2  Total Synthesis  3-dibromo-4  5-dihydroxyphenyl)-methane