The design strategy of selective PTP1B inhibitors over TCPTP

doi:10.1016/j.bmc.2016.06.035

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	The design strategy of selective PTP1B inhibitors over TCPTP
	Li, XiangQian ; Wang, LiJun ; Shi, DaYong 1
	2016-08-15
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY
卷号	24 期号:16 页码:3343-3352
文章类型	Review
摘要	Protein tyrosine phosphatase 1B (PTP1B) has already been well studied as a highly validated therapeutic target for diabetes and obesity. However, the lack of selectivity limited further studies and clinical applications of PTP1B inhibitors, especially over T-cell protein tyrosine phosphatase (TCPTP). In this review, we enumerate the published specific inhibitors of PTP1B, discuss the structure-activity relationships by analysis of their X-ray structures or docking results, and summarize the characteristic of selectivity related residues and groups. Furthermore, the design strategy of selective PTP1B inhibitors over TCPTP is also proposed. We hope our work could provide an effective way to gain specific PTP1B inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.
关键词	Selectivity Ptp1b Inhibitor Tcptp Diabetes Design Strategy
DOI	10.1016/j.bmc.2016.06.035
收录类别	SCI
语种	英语
WOS记录号	WOS:000380515700001
引用统计	被引频次：50[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/135858
专题	海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Li, XiangQian,Wang, LiJun,Shi, DaYong. The design strategy of selective PTP1B inhibitors over TCPTP[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2016,24(16):3343-3352.
APA	Li, XiangQian,Wang, LiJun,&Shi, DaYong.(2016).The design strategy of selective PTP1B inhibitors over TCPTP.BIOORGANIC & MEDICINAL CHEMISTRY,24(16),3343-3352.
MLA	Li, XiangQian,et al."The design strategy of selective PTP1B inhibitors over TCPTP".BIOORGANIC & MEDICINAL CHEMISTRY 24.16(2016):3343-3352.

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