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一种弯孢霉菌素类衍生物及其制备方法和应用 专利
专利类型: 发明, 专利号: CN201310309728.8, 申请日期: 2013-12-11, 公开日期: 2013-12-11
发明人:  王斌贵;  孟令红;  黄才国;  吕翠婷;  李晓明;  李春顺;  徐刚明
Adobe PDF(1370Kb)  |  收藏  |  浏览/下载:375/0  |  提交时间:2014/08/04
R3为h或r6co  一种弯孢霉菌素类衍生物  R4为h或含1‑20个碳原子的烷基或烷氧基  其特征在于:弯孢霉菌素类衍生物如式i所示  R5为氢或含1‑20个碳原子的直链或支链的烷基或烯基、苯基、取代苯基或含杂原子的芳香基  其中:r1、r2为h、r5co  R6为氢或含1‑20个碳原子的直链或支链的烷基或烯基、苯基、取代苯基或含杂原子的芳香基。fda00003546698100011.jpg  
Asperolide A, a Marine-Derived Tetranorditerpenoid, Induces G2/M Arrest in Human NCI-H460 Lung Carcinoma Cells, Is Mediated by p53-p21 Stabilization and Modulated by Ras/Raf/MEK/ERK Signaling Pathway 期刊论文
MARINE DRUGS, 2013, 卷号: 11, 期号: 2, 页码: 316-331
作者:  Lv, Cuiting;  Sun, Wenxia;  Sun, Haofen;  Wei, Shanjian;  Chen, Ruohua;  Wang, Bingui;  Huang, Caiguo;  Chen, RH
Adobe PDF(1126Kb)  |  收藏  |  浏览/下载:472/0  |  提交时间:2014/07/17
Asperolide a  G2/m Arrest  P53-p21  Ras/raf/mek/erk Signaling Pathway  
Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells 期刊论文
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2012, 卷号: 35, 期号: 11, 页码: 1964-1971
作者:  Zhang, Zhenwei;  Miao, Lei;  Sun, Weizhang;  Jiao, Binghua;  Wang, Bingui;  Yao, Li;  Huang, Caiguo;  Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
Adobe PDF(4919Kb)  |  收藏  |  浏览/下载:247/0  |  提交时间:2013/09/24
Wentilactone b  Apoptosis  Migration  Smmc-7721  Chang  
一种四降二萜双内酯类衍生物在制备抗肿瘤药物中的应用 专利
专利类型: 发明, 专利号: CN201110022009.9, 申请日期: 2012-07-18, 公开日期: 2012-07-18
发明人:  王斌贵;  孙好芬;  黄才国;  孟莉;  李晓明;  李春顺;  崔传明;  高书山
Adobe PDF(225Kb)  |  收藏  |  浏览/下载:410/0  |  提交时间:2014/08/04
一种四降二萜双内酯类衍生物在制备抗肿瘤药物中的应用。  
SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway 期刊论文
MARINE DRUGS, 2012, 卷号: 10, 期号: 6, 页码: 1345-1359
作者:  Zhao, Ying;  Chen, Huan;  Shang, Zhuo;  Jiao, Binghua;  Yuan, Bin;  Sun, Weizhang;  Wang, Bingui;  Miao, Mingyong;  Huang, Caiguo;  Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
Adobe PDF(1776Kb)  |  收藏  |  浏览/下载:402/0  |  提交时间:2013/09/24
Sd118-xanthocillin x (1)  Autophagy  Apoptosis  Erk  Beclin 1  
Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118 期刊论文
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2012, 卷号: 30, 期号: 2, 页码: 305-314
作者:  Shang Zhuo;  Li Xiaoming;  Meng Li;  Li Chunshun;  Gao Shushan;  Huang Caiguo;  Wang Bingui;  Huang, CG (reprint author), Mil Med Coll 2, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China.
Adobe PDF(526Kb)  |  收藏  |  浏览/下载:454/0  |  提交时间:2013/09/25
Bioguided Isolation  Deep-sea Sediment-derived Fungus  Penicillium Commune  Xanthocillin x  Antibacterial Activity  Cytotoxicity