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| Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells | |
Zhang, Zhenwei2; Miao, Lei3; Sun, Weizhang4; Jiao, Binghua2; Wang, Bingui1 ; Yao, Li3; Huang, Caiguo2; Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
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| 2012-11-01 | |
| 发表期刊 | BIOLOGICAL & PHARMACEUTICAL BULLETIN
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| ISSN | 0918-6158 |
| 卷号 | 35期号:11页码:1964-1971 |
| 文章类型 | Article |
| 摘要 | Wentilactone B (EN-48-57) is one of the six derivatives separated from Aspergillus wentii (EN-48). Of these derivatives, Wentilactone B exerted a more significant antibacterial and cytotoxic activity in several tumor cell lines. The present study demonstrates that Wentilactone B could efficiently induce SMMC-7721 cells apoptosis, but not normal hepatic cells, as measured by an inverted microscope, 4',6-diamidino-2-phenylindole staining and flow cytometry. In addition, Wentilactone B could inhibit the metastasis of SMMC-7721 cells, which was detected by colony formation, scratch migration and a transwell assay, and could induce a series of intracellular events, including the down-regulation of CD44 and epidermal growth factor receptor proteins. In conclusion, Wentilactone B inhibited the growth of SMMC-7721 cells by triggering apoptosis and inhibiting metastasis. |
| 关键词 | Wentilactone b Apoptosis Migration Smmc-7721 Chang |
| 学科领域 | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000310662700017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/12406 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China 3.Zhejiang Chinese Med Univ, Dept Pharmacol, Hangzhou 310053, Zhejiang, Peoples R China 4.Gen Hosp Chengdu Mil Command, PET Ctr, Chengdu 610083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhenwei,Miao, Lei,Sun, Weizhang,et al. Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2012,35(11):1964-1971. |
| APA | Zhang, Zhenwei.,Miao, Lei.,Sun, Weizhang.,Jiao, Binghua.,Wang, Bingui.,...&Wang, BG .(2012).Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells.BIOLOGICAL & PHARMACEUTICAL BULLETIN,35(11),1964-1971. |
| MLA | Zhang, Zhenwei,et al."Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells".BIOLOGICAL & PHARMACEUTICAL BULLETIN 35.11(2012):1964-1971. |
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