Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources

IOCAS-IR > 实验海洋生物学重点实验室

	Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources
	Lin, Xiukun 1; Liu, Ming 1; Hu, Chaoxin 1; Liao, D. Joshua 2
	2010-06-01
发表期刊	CURRENT DRUG TARGETS
卷号	11 期号:6 页码:708-715
文章类型	Review
摘要	Apoptosis as a form of programmed cell death is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. In an in vivo situation, apoptosis functions to eliminate potentially deleterious cells without causing such adverse effects as inflammatory response and ensuing scar formation. Therefore, targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Marine natural products have become an important source in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. Although lack of an analog of a long ethno-medical history for finding clues, as compared with terrestrial habitats, still hinders the progress, an increasing number of compounds have been isolated from marine organisms that have been found to possess apoptosis-inducing and anticancer activities. This primer summarizes several such compounds, based on their effects on apoptotic signaling pathways, although most of these products have not yet been studied in depth for their mechanisms of action.
关键词	Apoptosis Cancer Targets Marine Organisms Natural Products
收录类别	SCI
语种	英语
WOS记录号	WOS:000277123000006
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/32923
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Minnesota, Hormel Inst, Austin, MN 55912 USA
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Lin, Xiukun,Liu, Ming,Hu, Chaoxin,et al. Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources[J]. CURRENT DRUG TARGETS,2010,11(6):708-715.
APA	Lin, Xiukun,Liu, Ming,Hu, Chaoxin,&Liao, D. Joshua.(2010).Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources.CURRENT DRUG TARGETS,11(6),708-715.
MLA	Lin, Xiukun,et al."Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources".CURRENT DRUG TARGETS 11.6(2010):708-715.

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文件名称/大小	文献类型	版本类型	开放类型	使用许可
Targeting_Cellular_P（228KB）	期刊论文	出版稿	限制开放	ODC PDDL	浏览