| Synthesis and drug release in vitro of porphyran carrying 5-Fluorouracil | |
Zhang, Zhongshan1,2; Zhang, Quanbin1; Wang, Jing1,2 ; Shi, Xuelian1,2; Zhang, Jingjing1,2; Song, Houfang1,2
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| 2010-02-11 | |
| 发表期刊 | CARBOHYDRATE POLYMERS
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| 卷号 | 79期号:3页码:628-632 |
| 文章类型 | Article |
| 摘要 | Porphyran, the sulfated polysaccharide from red algae Porphyra haitanensis, possesses excellent bioactivities, especially the immune activity. In order to provide a water-soluble macromolecule prodrug of 5-FU showing slow release of 5-FU, reducing side-effect, we employed porphyran as a drug carrier, and carried out fixation of 5-FU to porphyran at 6-position through acetyl spacer group via ester bond. The chemical characteristic and release behavior of 5-FU from the conjugate obtained were studied in vitro at 37 degrees C in three different medium. The results represented that the release mechanism of all the conjugates was a typical Fickian diffusion. However, further in vivo studies on animal models are necessary to establish the efficiency of the system. (C) 2009 Elsevier Ltd. All rights reserved. |
| 关键词 | Porphyran 5-fluorouracil Drug Release In Vitro |
| DOI | 10.1016/j.carbpol.2009.09.009 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000273864500020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/32719 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Zhongshan,Zhang, Quanbin,Wang, Jing,et al. Synthesis and drug release in vitro of porphyran carrying 5-Fluorouracil[J]. CARBOHYDRATE POLYMERS,2010,79(3):628-632. |
| APA | Zhang, Zhongshan,Zhang, Quanbin,Wang, Jing,Shi, Xuelian,Zhang, Jingjing,&Song, Houfang.(2010).Synthesis and drug release in vitro of porphyran carrying 5-Fluorouracil.CARBOHYDRATE POLYMERS,79(3),628-632. |
| MLA | Zhang, Zhongshan,et al."Synthesis and drug release in vitro of porphyran carrying 5-Fluorouracil".CARBOHYDRATE POLYMERS 79.3(2010):628-632. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Synthesis and drug r（342KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
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