| The transcriptomic response to copper exposure by the gill tissue of Japanese scallops (Mizuhopecten yessoensis) using deep-sequencing technology | |
| Meng, Xiaolin1; Tian, Xue1; Liu, Mei2; Nie, Guoxing1; Jiang, Keyong2; Wang, Baojie2; Wang, Lei2; Liu, M (reprint author), Chinese Acad Sci, Inst Oceanol, R&D Ctr Marine, Qingdao 266071, Peoples R China. | |
| 2014-06-01 | |
| 发表期刊 | FISH & SHELLFISH IMMUNOLOGY
 |
| 卷号 | 38期号:2页码:287-293 |
| 文章类型 | Article |
| 摘要 | The bivalve Mizuhopecten yessoensis has been greatly impacted by marine pollutants in northern China. To elucidate the toxicological mechanism of copper exposure on the immune system, we investigated differentially expressed genes (DEGs) and transcript abundance in M. yessoensis gill tissue using the deep-sequencing platform Illumina HiSeq (TM) 2000. In total, 1312 and 2237 genes were identified as significantly up- or down-regulated, respectively. In addition, significant enrichment analysis identified 9 GO terms and 38 pathways involved in the response to copper exposure. The analysis of immune-related transcripts revealed a complex repertoire of innate recognition receptors, including toll-like receptors, NOD-like receptors and RIG-like receptors. Downstream pathway effectors, such as apoptotic, lysosomal and C-type lectin transcripts, were also analyzed. These results will provide a resource for subsequent gene expression studies regarding heavy metal exposure and the identification of copper-sensitive biomarkers to monitor the aquaculture of M. yessoensis. (C) 2014 Elsevier Ltd. All rights reserved. |
| 关键词 | Mizuhopecten Yessoensis Gill Copper Deep-sequencing |
| 学科领域 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| DOI | 10.1016/j.fsi.2014.03.009 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337014700003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/24248 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Liu, M (reprint author), Chinese Acad Sci, Inst Oceanol, R&D Ctr Marine, Qingdao 266071, Peoples R China. |
| 作者单位 | 1.Henan Normal Univ, Coll Fisheries, Xinxiang 453007, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, R&D Ctr Marine, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Xiaolin,Tian, Xue,Liu, Mei,et al. The transcriptomic response to copper exposure by the gill tissue of Japanese scallops (Mizuhopecten yessoensis) using deep-sequencing technology[J]. FISH & SHELLFISH IMMUNOLOGY,2014,38(2):287-293. |
| APA | Meng, Xiaolin.,Tian, Xue.,Liu, Mei.,Nie, Guoxing.,Jiang, Keyong.,...&Liu, M .(2014).The transcriptomic response to copper exposure by the gill tissue of Japanese scallops (Mizuhopecten yessoensis) using deep-sequencing technology.FISH & SHELLFISH IMMUNOLOGY,38(2),287-293. |
| MLA | Meng, Xiaolin,et al."The transcriptomic response to copper exposure by the gill tissue of Japanese scallops (Mizuhopecten yessoensis) using deep-sequencing technology".FISH & SHELLFISH IMMUNOLOGY 38.2(2014):287-293. |
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