| Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice | |
| Wei, Jianteng1,2,3; Wang, Shuxian4; Liu, Ge5; Pei, Dong1,2,3; Liu, Yongfeng1,2,3; Liu, Yi1,2,3; Di, Duolong1,2,3; Di, DL (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China. | |
| 2014-03-01 | |
| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 卷号 | 64页码:1-5 |
| 文章类型 | Article |
| 摘要 | The effects of polysaccharides from Enteromorpha prolifera (PEP) on cell-mediated immunity, humoral immunity and mononuclear phagocytic system function were evaluated to assess the immunomodulatory potential of these macromolecules. Relevant immunological mechanisms were verified by biochemical assays and western blot analysis. Results showed that PEP could induce splenocyte proliferation. In vivo experiments on Kunming mice confirmed that PEP could improve cell-mediated immunity, humoral immunity and mononuclear phagocytic system function. To illustrate the mechanism, we determined several immune-related enzymes in the thymus and spleen. The results indicated that PEP could enhance the activities of alkaline phosphatase, superoxide dismutase and lactate dehydrogenase. PEP could also increase the level of NF-kB. These results suggested that PEP exhibited potent immunomodulatory properties and could be used as a novel potential immunostimulant in food and pharmaceutical industries. (C) 2013 Elsevier B.V. All rights reserved. |
| 关键词 | Enteromoipha Prolifera Polysaccharide Immune Response Immune-related Enzyme Nf-kb |
| 学科领域 | Biochemistry & Molecular Biology |
| DOI | 10.1016/j.ijbiomac.2013.11.013 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334147300001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/24237 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Di, DL (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Ctr Resource Chem & New Mat, Qingdao 266100, Peoples R China 4.Mariculture Inst Shandong Prov, Qingdao 266002, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Jianteng,Wang, Shuxian,Liu, Ge,et al. Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2014,64:1-5. |
| APA | Wei, Jianteng.,Wang, Shuxian.,Liu, Ge.,Pei, Dong.,Liu, Yongfeng.,...&Di, DL .(2014).Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,64,1-5. |
| MLA | Wei, Jianteng,et al."Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 64(2014):1-5. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Polysaccharides from（731KB） | 限制开放 | ODC PDDL | 浏览 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论