Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms

doi:10.3390/md22050205

IOCAS-IR > 实验海洋生物学重点实验室

	Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms
	Geng, Hao1,2,3 ; Li, Rongfeng 1,2; Teng, Lichao 1,2,3; Yu, Chunlin1,2 ; Wang, Wenjie 1,2,3; Gao, Kun 1,2; Li, Aoyu 1,2,3; Liu, Song 1,2; Xing, Ronge1,2 ; Yu, Huahua1,2 ; Li, Pengcheng1,2
	2024-05-01
发表期刊	MARINE DRUGS
卷号	22 期号:5 页码:22
通讯作者	Yu, Huahua([email protected])
摘要	The escalation of jellyfish stings has drawn attention to severe skin reactions, underscoring the necessity for novel treatments. This investigation assesses the potential of hydroxybenzoic acid derivatives, specifically protocatechuic acid (PCA) and gentisic acid (DHB), for alleviating Nemopilema nomurai Nematocyst Venom (NnNV)-induced injuries. By employing an in vivo mouse model, the study delves into the therapeutic efficacy of these compounds. Through a combination of ELISA and Western blot analyses, histological examinations, and molecular assays, the study scrutinizes the inflammatory response, assesses skin damage and repair mechanisms, and investigates the compounds' ability to counteract venom effects. Our findings indicate that PCA and DHB significantly mitigate inflammation by modulating critical cytokines and pathways, altering collagen ratios through topical application, and enhancing VEGF and bFGF levels. Furthermore, both compounds demonstrate potential in neutralizing NnNV toxicity by inhibiting metalloproteinases and phospholipase-A2, showcasing the viability of small-molecule compounds in managing toxin-induced injuries.
关键词	jellyfish protocatechuic acid gentisic acid Nemopilema nomurai nematocyst venom skin necrosis inflammation
DOI	10.3390/md22050205
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:001233490300001
出版者	MDPI
WOS关键词	NOMURAI SCYPHOZOA RHIZOSTOMEAE ; NEMOPILEMA-NOMURAI ; INFLAMMATORY RESPONSE ; CRUDE VENOM ; BLOOMS ; METALLOPROTEINASE ; ENVENOMATION ; MATRIX
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/185964
专题	实验海洋生物学重点实验室
通讯作者	Yu, Huahua
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Geng, Hao,Li, Rongfeng,Teng, Lichao,et al. Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms[J]. MARINE DRUGS,2024,22(5):22.
APA	Geng, Hao.,Li, Rongfeng.,Teng, Lichao.,Yu, Chunlin.,Wang, Wenjie.,...&Li, Pengcheng.(2024).Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms.MARINE DRUGS,22(5),22.
MLA	Geng, Hao,et al."Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms".MARINE DRUGS 22.5(2024):22.