Evaluation of the chronic toxicity of bisphenol A and bisphenol AF to sea cucumber <i>Apostichopus japonicus</i> after long-term single and combined exposure at environmental relevant concentration

doi:10.1016/j.envres.2024.118748

	*Evaluation of the chronic toxicity of bisphenol A and bisphenol AF to sea cucumber Apostichopus japonicus* after long-term single and combined exposure at environmental relevant concentration**
	Lai, Kaiqi1,2,3 ; Zhang, Libin 1,2,3; Xu, Jialei 4
	2024-06-15
发表期刊	ENVIRONMENTAL RESEARCH
ISSN	0013-9351
卷号	251 页码:10
通讯作者	Zhang, Libin([email protected])
摘要	Bisphenols are emerging endocrine disrupting pollutant, and several studies have reported that they are already ubiquitous in various environmental matrices and intend to deposit in sediment. The primary sources of bisphenols are river and sewage discharge. Sea cucumber ( Apostichopus japonicus ), a typical deposit feeder, is one of the most important commercial marine species in Aisa. However, the effects of the bisphenol A (BPA) and its analogues bisphenol AF (BPAF) on sea cucumber was unclear. In this study, we carried out field survey in major sea cucumber farming areas in northern China, with the aim of determining which bisphenol analogue is the major bisphenol contamination in this aquaculture area. The results showed that the presence of BPAF was detected in four sampling sites (Dalian, Tangshan, Laizhou, and Longpan). The mean level of BPAF in Laizhou sediment samples was the highest which reached to 9.007 +/- 4.702 mu g/kg. Among the seawater samples, the BPAF only have been detected in the samples collected at Longpan. (0.011 +/- 0.003 mu g/L). Furthermore, we conducted an experiment to evaluate the single and combined toxicity of BPA and BPAF on sea cucumbers. The concentrations were informed by the findings based on the results of field research. (0.1, 1.0, and 10 mu g/L). After exposure, the body weight gain, and specific growth rate showed no significant changes ( P > 0.05). We observed the histological alterations in respiratory tree of treated sea cucumbers including the fusion and detachment of lining epithelial tissue, and increase of lumen space. However, the catalase (CAT), malondialdehyde (MDA), and glutathione (GSH) activity was not significantly changed ( P > 0.05). We evaluated the effects of BPA and BPAF through calculating the integrated biomarker response index (IBR), and the results indicated that the toxicity of combined treatment was higher than single treatment. Additionally, BPAF exposure to A . japonicus was more toxic than BPA.
关键词	Bisphenol Endocrine disruptor Histological alterations Integrated biomarker response Sea cucumbers
DOI	10.1016/j.envres.2024.118748
收录类别	SCI
语种	英语
资助项目	National Key Research and Devel-opment Program of China[2023YFD2401105]
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health
WOS记录号	WOS:001223325500001
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词	INTEGRATED BIOMARKER RESPONSE ; SEDIMENTS ; ACCUMULATION ; REPRODUCTION ; GROWTH
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/185791
专题	海洋生态与环境科学重点实验室
通讯作者	Zhang, Libin
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shandong Tonhe Ocean Technol Co Ltd, Dongying 257200, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Lai, Kaiqi,Zhang, Libin,Xu, Jialei. Evaluation of the chronic toxicity of bisphenol A and bisphenol AF to sea cucumber Apostichopus japonicus after long-term single and combined exposure at environmental relevant concentration[J]. ENVIRONMENTAL RESEARCH,2024,251:10.
APA	Lai, Kaiqi,Zhang, Libin,&Xu, Jialei.(2024).Evaluation of the chronic toxicity of bisphenol A and bisphenol AF to sea cucumber Apostichopus japonicus after long-term single and combined exposure at environmental relevant concentration.ENVIRONMENTAL RESEARCH,251,10.
MLA	Lai, Kaiqi,et al."Evaluation of the chronic toxicity of bisphenol A and bisphenol AF to sea cucumber Apostichopus japonicus after long-term single and combined exposure at environmental relevant concentration".ENVIRONMENTAL RESEARCH 251(2024):10.