Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis | |
Yu, Chunlin1,3; Yin, Xiujing1,3; Li, Aoyu1,3; Li, Rongfeng1,2; Yu, Huahua1,2; Xing, Ronge1,2; Liu, Song1,2; Li, Pengcheng1,2 | |
2024-02-10 | |
发表期刊 | JOURNAL OF PROTEOMICS |
ISSN | 1874-3919 |
卷号 | 292页码:13 |
通讯作者 | Yu, Huahua([email protected]) |
摘要 | Toxin metalloproteinases are the primary components responsible for various toxicities in jellyfish venom, and there is still no effective specific therapy for jellyfish stings. The comprehension of the pathogenic mechanisms underlying toxin metalloproteinases necessitates further refinement. In this study, we conducted a differential analysis of a dermatitis mouse model induced by jellyfish Nemopilema nomurai venom (NnNV) samples with varying levels of metalloproteinase activity. Through skin tissue proteomics and serum metabolomics, the predominant influence of toxin metalloproteinase activity on inflammatory response was revealed, and the signal pathway involved in its regulation was identified. In skin tissues, many membrane proteins were significantly down-regulated, which might cause tissue damage. The expression of pro-inflammatory factors was mainly regulated by PI3K-Akt signaling pathway. In serum, many fatty acid metabolites were significantly down regulated, which might be the anti-inflammation feedback regulated by NF-kappa B p65 signaling pathway. These results reveal the dermatitis mechanism of toxin metalloproteinases and provide new therapeutic targets for further studies.Significance: Omics is an important method to analyze the pathological mechanism and discover the key markers, which can reveal the pathological characteristics of jellyfish stings. Our research first analyzed the impact of toxin metalloproteinases on jellyfish sting dermatitis by skin proteomics and serum metabolomics. The present results suggest that inhibition of toxin metalloproteinases may be an effective treatment strategy, and provide new references for further jellyfish sting studies. |
关键词 | Jellyfish sting Metalloproteinase Differential analysis Signal pathway Dermatitis mechanism |
DOI | 10.1016/j.jprot.2023.105048 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[42306143]; National Natural Science Foundation of China[41776163]; National Natural Science Foundation of China[41876164]; China Postdoctoral Science Foundation[2023M733532]; National Key R&D Program of China[2019YFC0312605]; National Key R&D Program of China[2017YFE0111100-04]; Natural Science Foundation of Shandong Province[ZR2019QD012]; Postdoctoral Project Foundation of Qingdao[QDBSH20220202179] |
WOS研究方向 | Biochemistry & Molecular Biology |
WOS类目 | Biochemical Research Methods |
WOS记录号 | WOS:001124796400001 |
出版者 | ELSEVIER |
WOS关键词 | NEMOPILEMA-NOMURAI SCYPHOZOA ; CHIRONEX-FLECKERI ; YELLOW SEA ; PROTEIN ; VENOM ; RHIZOSTOMEAE ; ADHESION ; MODULATION ; MUTATIONS ; FAMILY |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/184177 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Yu, Huahua |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China |
第一作者单位 | 中国科学院海洋研究所 |
通讯作者单位 | 中国科学院海洋研究所 |
推荐引用方式 GB/T 7714 | Yu, Chunlin,Yin, Xiujing,Li, Aoyu,et al. Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis[J]. JOURNAL OF PROTEOMICS,2024,292:13. |
APA | Yu, Chunlin.,Yin, Xiujing.,Li, Aoyu.,Li, Rongfeng.,Yu, Huahua.,...&Li, Pengcheng.(2024).Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis.JOURNAL OF PROTEOMICS,292,13. |
MLA | Yu, Chunlin,et al."Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis".JOURNAL OF PROTEOMICS 292(2024):13. |
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