IOCAS-IR  > 实验海洋生物学重点实验室
Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis
Yu, Chunlin1,3; Yin, Xiujing1,3; Li, Aoyu1,3; Li, Rongfeng1,2; Yu, Huahua1,2; Xing, Ronge1,2; Liu, Song1,2; Li, Pengcheng1,2
2024-02-10
发表期刊JOURNAL OF PROTEOMICS
ISSN1874-3919
卷号292页码:13
通讯作者Yu, Huahua([email protected])
摘要Toxin metalloproteinases are the primary components responsible for various toxicities in jellyfish venom, and there is still no effective specific therapy for jellyfish stings. The comprehension of the pathogenic mechanisms underlying toxin metalloproteinases necessitates further refinement. In this study, we conducted a differential analysis of a dermatitis mouse model induced by jellyfish Nemopilema nomurai venom (NnNV) samples with varying levels of metalloproteinase activity. Through skin tissue proteomics and serum metabolomics, the predominant influence of toxin metalloproteinase activity on inflammatory response was revealed, and the signal pathway involved in its regulation was identified. In skin tissues, many membrane proteins were significantly down-regulated, which might cause tissue damage. The expression of pro-inflammatory factors was mainly regulated by PI3K-Akt signaling pathway. In serum, many fatty acid metabolites were significantly down regulated, which might be the anti-inflammation feedback regulated by NF-kappa B p65 signaling pathway. These results reveal the dermatitis mechanism of toxin metalloproteinases and provide new therapeutic targets for further studies.Significance: Omics is an important method to analyze the pathological mechanism and discover the key markers, which can reveal the pathological characteristics of jellyfish stings. Our research first analyzed the impact of toxin metalloproteinases on jellyfish sting dermatitis by skin proteomics and serum metabolomics. The present results suggest that inhibition of toxin metalloproteinases may be an effective treatment strategy, and provide new references for further jellyfish sting studies.
关键词Jellyfish sting Metalloproteinase Differential analysis Signal pathway Dermatitis mechanism
DOI10.1016/j.jprot.2023.105048
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[42306143]; National Natural Science Foundation of China[41776163]; National Natural Science Foundation of China[41876164]; China Postdoctoral Science Foundation[2023M733532]; National Key R&D Program of China[2019YFC0312605]; National Key R&D Program of China[2017YFE0111100-04]; Natural Science Foundation of Shandong Province[ZR2019QD012]; Postdoctoral Project Foundation of Qingdao[QDBSH20220202179]
WOS研究方向Biochemistry & Molecular Biology
WOS类目Biochemical Research Methods
WOS记录号WOS:001124796400001
出版者ELSEVIER
WOS关键词NEMOPILEMA-NOMURAI SCYPHOZOA ; CHIRONEX-FLECKERI ; YELLOW SEA ; PROTEIN ; VENOM ; RHIZOSTOMEAE ; ADHESION ; MODULATION ; MUTATIONS ; FAMILY
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/184177
专题实验海洋生物学重点实验室
通讯作者Yu, Huahua
作者单位1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
推荐引用方式
GB/T 7714
Yu, Chunlin,Yin, Xiujing,Li, Aoyu,et al. Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis[J]. JOURNAL OF PROTEOMICS,2024,292:13.
APA Yu, Chunlin.,Yin, Xiujing.,Li, Aoyu.,Li, Rongfeng.,Yu, Huahua.,...&Li, Pengcheng.(2024).Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis.JOURNAL OF PROTEOMICS,292,13.
MLA Yu, Chunlin,et al."Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis".JOURNAL OF PROTEOMICS 292(2024):13.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yu, Chunlin]的文章
[Yin, Xiujing]的文章
[Li, Aoyu]的文章
百度学术
百度学术中相似的文章
[Yu, Chunlin]的文章
[Yin, Xiujing]的文章
[Li, Aoyu]的文章
必应学术
必应学术中相似的文章
[Yu, Chunlin]的文章
[Yin, Xiujing]的文章
[Li, Aoyu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。