Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet

doi:10.1016/j.jff.2021.104642

IOCAS-IR > 实验海洋生物学重点实验室

	Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet
	Deng, Zhenzhen 1,2,3; Wu, Ning 1; Wang, Jing1,2 ; Zhang, Quanbin 1,2
	2021-10-01
发表期刊	JOURNAL OF FUNCTIONAL FOODS
ISSN	1756-4646
卷号	85 页码:11
通讯作者	Wang, Jing([email protected]) ; Zhang, Quanbin([email protected])
摘要	Metabolic syndrome (MetS) is a pathological state of multiple metabolic abnormalities. Dietary fibers (DFs) has been widely concerned about its positive role in MetS. Different from the DFs of terrestrial plants, the DFs of seaweeds has unique composition and structural characteristics. The aim of this study is to investigate the composition and microstructures of DF derived from Saccharina japonica, and its positive effects on MetS mice induced by high fat diet (HFD). We extracted DF from S. japonica (DFSJ). DFSJ has a high proportion of soluble dietary fiber (SDF) and it shows good water holding capacity (11.34 +/- 1.63 g/g) and swelling property (32.9 +/- 2.52 mL/g). Supplementing DFSJ can significantly improve insulin resistance (IR), dyslipidemia in HFD mice. Besides, DFSJ can reduce inflammatory factors (TNF-alpha, MCP-1 and IL-6), improve the hepatic oxidative stress and protect visceral organs from the injury of HFD. Finally, 16S rDNA high-throughput sequencing was used to further analyze the profile changes of gut microbiota. The results indicated that supplementing DFSJ can effectively ameliorate gut microbiota dysbiosis. In particular, DFSJ can increase the relative abundance of some beneficial bacteria, such as Bifidobacterium, Turicibacter and Akkermansia. Our results indicated that DFSJ has a comprehensive regulatory effect on MetS, and it is involved in various regulatory pathways, such as antioxidant, anti-inflammatory, hypoglycemic and hypolipidemic pathways in HFD-induced MetS mice. Our results reveal the great potential of DFSJ as an effective regulator on various metabolic abnormalities of MetS.
关键词	Dietary fiber Insulin resistance Metabolic syndrome Gut microbiota
DOI	10.1016/j.jff.2021.104642
收录类别	SCI
语种	英语
资助项目	National Key RD Plan of China[2018YFD0901104]; Special Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao Pilot National Laboratory for Marine Science and Technology[OF2020NO02]; Major Scientific & Engineering Projects of Innovation in Shandong Province[2019JZZY010818]; K.C. Wong Education Foundation, CAS
WOS研究方向	Food Science & Technology ; Nutrition & Dietetics
WOS类目	Food Science & Technology ; Nutrition & Dietetics
WOS记录号	WOS:000686899700006
出版者	ELSEVIER
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/176240
专题	实验海洋生物学重点实验室
通讯作者	Wang, Jing; Zhang, Quanbin
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Deng, Zhenzhen,Wu, Ning,Wang, Jing,et al. Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet[J]. JOURNAL OF FUNCTIONAL FOODS,2021,85:11.
APA	Deng, Zhenzhen,Wu, Ning,Wang, Jing,&Zhang, Quanbin.(2021).Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet.JOURNAL OF FUNCTIONAL FOODS,85,11.
MLA	Deng, Zhenzhen,et al."Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet".JOURNAL OF FUNCTIONAL FOODS 85(2021):11.

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