Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress

doi:10.1038/s41598-020-63122-4

IOCAS-IR > 实验海洋生物学重点实验室

	Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress
	Xu, Fei 1; Gao, Tingting1,3 ; Liu, Xiao 1,2
	2020-04-14
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	10 期号:1 页码:11
摘要	Temperature fluctuation is a key abiotic factor for the growth and survival of Pacific abalone Haliotis discus hannai, particularly during climate change. However, the physiological mechanism underlying the abalones' response to heat stress remains unknown. We sought to understand the metabolic adaptation mechanism of Pacific abalone to heat stress for further analyzing its heat tolerance capacity. For two groups experienced different acclimate temperature (10 degrees C and 30 degrees C for 62 days), the Pacific abalone juveniles displayed significantly different survival rates under 31 degrees C acute heat treatment. A total of 1815 and 1314 differential metabolites were identified from the 10 degrees C and 30 degrees C acclimate groups respectively, by comparing mass spectrometry data of the samples before and after heat stimulation. Heat stress led to mitochondrial failure, resulting in incomplete oxidative metabolism of amino acids and fatty acids in the mitochondria, and massive accumulation of unstable metabolic intermediates in cells. The 10 degrees C acclimated group accumulated more harmful substances after heat stimulation, provoking further stress responses and pathophysiological processes. In comparison, the 30 degrees C acclimated group showed stronger regulation capacity to produce beneficial substances for metabolic homeostasis. The findings provided insight into the heat response of marine animals, especially concerning mitochondrial metabolism.
DOI	10.1038/s41598-020-63122-4
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41776152]; National Natural Science Foundation of China[41676152]; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province[2017LZGC009]; Key Deployment Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Science[COMS2019Q11]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000562162800031
出版者	NATURE PUBLISHING GROUP
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/168289
专题	实验海洋生物学重点实验室
通讯作者	Xu, Fei
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Mega Sci, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Zhejiang Ocean Univ, Key Lab Marine Fishery Equipment & Technol Zhejia, Fishery Coll, Zhoushan 316022, Peoples R China 3.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Xu, Fei,Gao, Tingting,Liu, Xiao. Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress[J]. SCIENTIFIC REPORTS,2020,10(1):11.
APA	Xu, Fei,Gao, Tingting,&Liu, Xiao.(2020).Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress.SCIENTIFIC REPORTS,10(1),11.
MLA	Xu, Fei,et al."Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress".SCIENTIFIC REPORTS 10.1(2020):11.

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