| The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica | |
Jin, Weihua1,2,3; Wang, Jing1,3 ; Jiang, Hong4; Song, Ning4; Zhang, Wenjing1,2; Zhang, Quanbin1,3; Zhang, QB
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| 2013-08-14 | |
| 发表期刊 | CARBOHYDRATE POLYMERS
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| ISSN | 0144-8617 |
| 卷号 | 97期号:1页码:116-120 |
| 文章类型 | Article |
| 摘要 | Crude fucoidan extracted from Saccharina japonica was separated by anion-exchange chromatography. Then, the neuroprotective activities of the crude fucoidan (J) and its fractions (J0.4, J0.5, J1 and J2) were tested. J, J0.4 and J0.5 were shown to have neuroprotective effects. To simplify the structural features of the compounds, crude fucoidan was degraded to obtain low molecular weight fucoidan (DJ). DJ was further fractionated into DJ0.5, DJ1 and DJ2, and the neuroprotective activities of these fractions were determined. This analysis revealed that DJ and DJ0.5 retained the neuroprotective activity. However, the DJ0.5 fraction remained very complex. Thus, DJ0.5 was further separated into six fractions (F0.1, F0.2, F0.3, F0.4, F0.5 and F1). Finally, it was concluded that the anion-exchange fractions F0.1, F0.2 and F0.3 exhibited neuroprotective activities. These results suggest that heteropolysaccharides might contribute to the neuroprotective activity. Moreover, the neuroprotective heteropolysaccharide fractions contained relatively low fucose (less than 20%) and sulfate (25%), high UA content (more than 10%) and a high molar ratio of all other monosaccharides (C) 2013 Elsevier Ltd. All rights reserved.; Crude fucoidan extracted from Saccharina japonica was separated by anion-exchange chromatography. Then, the neuroprotective activities of the crude fucoidan (J) and its fractions (J0.4, J0.5, J1 and J2) were tested. J, J0.4 and J0.5 were shown to have neuroprotective effects. To simplify the structural features of the compounds, crude fucoidan was degraded to obtain low molecular weight fucoidan (DJ). DJ was further fractionated into DJ0.5, DJ1 and DJ2, and the neuroprotective activities of these fractions were determined. This analysis revealed that DJ and DJ0.5 retained the neuroprotective activity. However, the DJ0.5 fraction remained very complex. Thus, DJ0.5 was further separated into six fractions (F0.1, F0.2, F0.3, F0.4, F0.5 and F1). Finally, it was concluded that the anion-exchange fractions F0.1, F0.2 and F0.3 exhibited neuroprotective activities. These results suggest that heteropolysaccharides might contribute to the neuroprotective activity. Moreover, the neuroprotective heteropolysaccharide fractions contained relatively low fucose (less than 20%) and sulfate (25%), high UA content (more than 10%) and a high molar ratio of all other monosaccharides (C) 2013 Elsevier Ltd. All rights reserved. |
| 关键词 | Heteropolysaccharide Neuroprotective Activity Saccharina Japonica |
| 学科领域 | Chemistry ; Polymer Science |
| DOI | 10.1016/j.carbpol.2013.04.055 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Chemistry ; Polymer Science |
| WOS类目 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| WOS记录号 | WOS:000321167300017 |
| WOS关键词 | HIZIKIA-FUSIFORME ; SULFATED POLYSACCHARIDES ; ANTICOAGULANT ACTIVITY ; LAMINARIA-JAPONICA ; BROWN SEAWEED ; CID-MS/MS ; FUCOIDAN ; CELLS |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/16727 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Zhang, QB |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.IOCAS, Nantong Marine Sci & Technol R&D Ctr, Nantong 226006, Jiangsu, Peoples R China 4.Qingdao Univ, Dept Physiol, Coll Med, Qingdao 266071, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Jin, Weihua,Wang, Jing,Jiang, Hong,et al. The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica[J]. CARBOHYDRATE POLYMERS,2013,97(1):116-120. |
| APA | Jin, Weihua.,Wang, Jing.,Jiang, Hong.,Song, Ning.,Zhang, Wenjing.,...&Zhang, QB.(2013).The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica.CARBOHYDRATE POLYMERS,97(1),116-120. |
| MLA | Jin, Weihua,et al."The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica".CARBOHYDRATE POLYMERS 97.1(2013):116-120. |
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