Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Triazoles and Other N-Containing Metabolites from the Marine-Derived Endophytic Fungus Penicillium chrysogenum EN-118 | |
An, Chun-Yan1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Gao, Shu-Shan1,2; Shang, Zhuo1,2; Wang, Bin-Gui1 ; Wang, BG
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| 2013-04-01 | |
| 发表期刊 | HELVETICA CHIMICA ACTA
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| ISSN | 0018-019X |
| 卷号 | 96期号:4页码:682-687 |
| 文章类型 | Article |
| 摘要 | Two new triazoles, chrysotriazoles A and B (1 and 2, resp.), along with two known quinazolinones, 3 and 4, two known 2-(4-hydroxyphenyl)acetamides, 5 and 6, and two known N-(4-hydroxystyryl)formamides, 7 and 8, were isolated and identified from the culture extract of Penicillium chrysogenum EN-118, an endophytic fungus obtained from the marine brown alga Sargassum pallidium. The structures of the isolated compounds were elucidated by NMR-spectroscopic analysis, and that of compound 1 was confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative. Compounds 4, 5, and 7 showed moderate cytotoxicities against Du145, A-549, and HeLa cell lines.; Two new triazoles, chrysotriazoles A and B (1 and 2, resp.), along with two known quinazolinones, 3 and 4, two known 2-(4-hydroxyphenyl)acetamides, 5 and 6, and two known N-(4-hydroxystyryl)formamides, 7 and 8, were isolated and identified from the culture extract of Penicillium chrysogenum EN-118, an endophytic fungus obtained from the marine brown alga Sargassum pallidium. The structures of the isolated compounds were elucidated by NMR-spectroscopic analysis, and that of compound 1 was confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative. Compounds 4, 5, and 7 showed moderate cytotoxicities against Du145, A-549, and HeLa cell lines. |
| 关键词 | Sargassum Pallidium Penicillium Chrysogenum Chrysotriazoles a And b Cytotoxic Activity |
| 学科领域 | Chemistry |
| DOI | 10.1002/hlca.201200433 |
| URL | 查看原文 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000317492200012 |
| WOS关键词 | ASPERGILLUS-OCHRACEUS ; CHAETOMIUM-GLOBOSUM ; NATURAL-PRODUCTS ; ESSRAMYCIN ; ALKALOIDS ; STEROIDS ; QEN-24S ; NIGER |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/16669 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, BG |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | An, Chun-Yan,Li, Xiao-Ming,Li, Chun-Shun,et al. Triazoles and Other N-Containing Metabolites from the Marine-Derived Endophytic Fungus Penicillium chrysogenum EN-118[J]. HELVETICA CHIMICA ACTA,2013,96(4):682-687. |
| APA | An, Chun-Yan.,Li, Xiao-Ming.,Li, Chun-Shun.,Gao, Shu-Shan.,Shang, Zhuo.,...&Wang, BG.(2013).Triazoles and Other N-Containing Metabolites from the Marine-Derived Endophytic Fungus Penicillium chrysogenum EN-118.HELVETICA CHIMICA ACTA,96(4),682-687. |
| MLA | An, Chun-Yan,et al."Triazoles and Other N-Containing Metabolites from the Marine-Derived Endophytic Fungus Penicillium chrysogenum EN-118".HELVETICA CHIMICA ACTA 96.4(2013):682-687. |
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