Targeting cellular apoptotic pathway with peptides from marine organisms

doi:10.1016/j.bbcan.2013.02.006

IOCAS-IR > 实验海洋生物学重点实验室

	Targeting cellular apoptotic pathway with peptides from marine organisms
	Zheng, Lanhong 1; Lin, Xiukun 2; Wu, Ning 3; Liu, Ming 3; Zheng, Yuan 1; Sheng, Jun 1; Ji, Xiaofeng 1; Sun, Mi 1; Lin, XK
	2013-08-01
发表期刊	BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
ISSN	0304-419X
卷号	1836 期号:1 页码:42-48
文章类型	Review
摘要	Apoptosis is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. Targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Peptides from marine organisms have become important sources in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. This primer summarizes several marine peptides, based on their effects on apoptotic signaling pathways, although most of these peptides have not yet been studied in depth for their mechanisms of action. Novel peptides that induce an apoptosis signal pathway are presented in association with their pharmacological properties. (C) 2013 Elsevier B.V. All rights reserved.; Apoptosis is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. Targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Peptides from marine organisms have become important sources in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. This primer summarizes several marine peptides, based on their effects on apoptotic signaling pathways, although most of these peptides have not yet been studied in depth for their mechanisms of action. Novel peptides that induce an apoptosis signal pathway are presented in association with their pharmacological properties. (C) 2013 Elsevier B.V. All rights reserved.
关键词	Apoptosis Marine Organisms Peptides
学科领域	Biochemistry & Molecular Biology ; Biophysics ; Oncology
DOI	10.1016/j.bbcan.2013.02.006
URL	查看原文
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Oncology
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Oncology
WOS记录号	WOS:000320475800004
WOS关键词	BCL-2 FAMILY PROTEINS ; FACTOR-KAPPA-B ; CANCER-THERAPY ; BRENTUXIMAB VEDOTIN ; DIDEMNIN-B ; IN-VITRO ; PM02734 ELISIDEPSIN ; SOMOCYSTINAMIDE-A ; ANTICANCER AGENTS ; CLINICAL-TRIALS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/16639
专题	实验海洋生物学重点实验室
通讯作者	Lin, XK
作者单位	1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China 2.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Lanhong,Lin, Xiukun,Wu, Ning,et al. Targeting cellular apoptotic pathway with peptides from marine organisms[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER,2013,1836(1):42-48.
APA	Zheng, Lanhong.,Lin, Xiukun.,Wu, Ning.,Liu, Ming.,Zheng, Yuan.,...&Lin, XK.(2013).Targeting cellular apoptotic pathway with peptides from marine organisms.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER,1836(1),42-48.
MLA	Zheng, Lanhong,et al."Targeting cellular apoptotic pathway with peptides from marine organisms".BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1836.1(2013):42-48.

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