Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| 4-Phenyl-3,4-dihydroquinolone Derivatives from Aspergillus nidulans MA-143, an Endophytic Fungus Isolated from the Mangrove Plant Rhizophora stylosa | |
An, Chun-Yan1,2; Li, Xiao-Ming1; Luo, Han1,2; Li, Chun-Shun1; Wang, Ming-Hui1,2; Xu, Gang-Ming1; Wang, Bin-Gui1 ; Wang, BG
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| 2013-10-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 76期号:10页码:1896-1901 |
| 文章类型 | Article |
| 摘要 | Six new 4-phenyl-3,4-dihydroquinolone derivatives (1-6) along with the related aflaquinolone A (7) were isolated and identified from the cultures of Aspergillus nidulans MA-143, an endophytic fungus obtained from the fresh leaves of the marine mangrove plant Rhizophora stylosa. Their structures including absolute configurations were determined by spectroscopic analysis and electronic circular dichroism experiments, and the structure of compound 1 was confirmed by single-crystal X-ray crystallographic analysis. In bioscreening experiments, none of the isolated compounds showed potent antibacterial or cytotoxic activity. However, compounds 2, 3, and 7 exhibited lethality against brine shrimp (Artemia sauna), with LD50 values of 7.1, 4.5, and 5.5 mu M, respectively.; Six new 4-phenyl-3,4-dihydroquinolone derivatives (1-6) along with the related aflaquinolone A (7) were isolated and identified from the cultures of Aspergillus nidulans MA-143, an endophytic fungus obtained from the fresh leaves of the marine mangrove plant Rhizophora stylosa. Their structures including absolute configurations were determined by spectroscopic analysis and electronic circular dichroism experiments, and the structure of compound 1 was confirmed by single-crystal X-ray crystallographic analysis. In bioscreening experiments, none of the isolated compounds showed potent antibacterial or cytotoxic activity. However, compounds 2, 3, and 7 exhibited lethality against brine shrimp (Artemia sauna), with LD50 values of 7.1, 4.5, and 5.5 mu M, respectively. |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1021/np4004646 |
| URL | 查看原文 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| WOS类目 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000326319700011 |
| WOS关键词 | PENICILLIUM SP ; MARINE ; BIOSYNTHESIS ; ALKALOIDS ; CONSTITUENTS ; METABOLITES |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/16507 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, BG |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | An, Chun-Yan,Li, Xiao-Ming,Luo, Han,et al. 4-Phenyl-3,4-dihydroquinolone Derivatives from Aspergillus nidulans MA-143, an Endophytic Fungus Isolated from the Mangrove Plant Rhizophora stylosa[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(10):1896-1901. |
| APA | An, Chun-Yan.,Li, Xiao-Ming.,Luo, Han.,Li, Chun-Shun.,Wang, Ming-Hui.,...&Wang, BG.(2013).4-Phenyl-3,4-dihydroquinolone Derivatives from Aspergillus nidulans MA-143, an Endophytic Fungus Isolated from the Mangrove Plant Rhizophora stylosa.JOURNAL OF NATURAL PRODUCTS,76(10),1896-1901. |
| MLA | An, Chun-Yan,et al."4-Phenyl-3,4-dihydroquinolone Derivatives from Aspergillus nidulans MA-143, an Endophytic Fungus Isolated from the Mangrove Plant Rhizophora stylosa".JOURNAL OF NATURAL PRODUCTS 76.10(2013):1896-1901. |
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