Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test

doi:10.1016/j.toxicon.2019.11.005

	Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test
	Wang, Shuqin 1,2; Qiu, Jiangbing 1,2; Zhao, Mingyue 1,2; Li, Fangxiao 1,2; Yu, Rencheng 3; Li, Aifeng 1,2
	2020-01-15
发表期刊	TOXICON
ISSN	0041-0101
卷号	173 页码:39-47
通讯作者	Li, Aifeng([email protected])
摘要	Neurotoxin beta-N-methylamino-L-alanine (BMAA) has been widely detected in diverse aquatic organisms within diffefent ecosystem trophic levels in recent years. It was the goal of this study to investigate the accumulation and tissue distribution of BMAA in marine opossum shrimp (Neomysis awatschensis) and freshwater zebrafish (Danio rerio) in exposure experiments. A T-maze test was tentatively adopted to assess the effects of BMAA on the learning and memory ability of zebrafish. Interestingly, N. awatschensis was testified to be capable of accumulating free soluble BMAA from bathing seawater through a biological filtration pathway (max. 110.6 mu g g(-1) wet weight). BMAA was transferred quickly from viscus to muscle and head tissues of zebrafish after intraperitoneal administration of 16.3 mu g BMAA per individual twice in two weeks. BMAA accumulated mainly as the total soluble form in both experimental organisms. Results do not support the hypothesis that free BMAA molecules can be largely incorporated into protein in aquatic animals. Behavior of zebrafish in the T-maze test demonstrated that the short-term learning and memory ability was negatively impacted to some degree after three-days exposure to BMAA. Moreover, on Day 3, certain individual zebrafish exhibited freezing and loitering behavior. However, further investigation will be required to discern the long-term effects of BMAA on animals in order to evaluate the risk of BMAA exposure to human health.
关键词	beta-N-mothylamino-L-alanine (BMAA) Toxin accumulation Opossum shrimp Zebrafish T-maze test
DOI	10.1016/j.toxicon.2019.11.005
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41676093]###3665; Fundamental Research Funds for the Central Universities, China[201841003]###3666; National Natural Science Foundation of China[41676093]; Fundamental Research Funds for the Central Universities, China[201841003]
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
WOS类目	Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:000508739100005
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/164413
专题	海洋生态与环境科学重点实验室
通讯作者	Li, Aifeng
作者单位	1.Ocean Univ China, Coll Environm Sci & Engn, Qingdao 266100, Peoples R China 2.Ocean Univ China, Key Lab Marine Environm & Ecol, Minist Educ, Qingdao 266100, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shuqin,Qiu, Jiangbing,Zhao, Mingyue,et al. Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test[J]. TOXICON,2020,173:39-47.
APA	Wang, Shuqin,Qiu, Jiangbing,Zhao, Mingyue,Li, Fangxiao,Yu, Rencheng,&Li, Aifeng.(2020).Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test.TOXICON,173,39-47.
MLA	Wang, Shuqin,et al."Accumulation and distribution of neurotoxin BMAA in aquatic animals and effect on the behavior of zebrafish in a T-maze test".TOXICON 173(2020):39-47.

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