Characterization of Cladosporols from the Marine Algal-Derived Endophytic Fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives

doi:10.1021/acs.joc.7b01277

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	Characterization of Cladosporols from the Marine Algal-Derived Endophytic Fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives
	Li, Hong-Lei1,2 ; Li, Xiao-Ming 1; Attila Mandi 3; Antus, Sandor 3; Li, Xin1 ; Zhang, Peng 1,2; Liu, Yang 1,2; Tibor Kurtan 3; Wang, Bin-Gui1
	2017-10-06
发表期刊	JOURNAL OF ORGANIC CHEMISTRY
ISSN	0022-3263
卷号	82 期号:19 页码:9946-9954
通讯作者	Tibor Kurtan([email protected]) ; Wang, Bin-Gui([email protected])
摘要	Four new cladosporol derivatives, cladosporols F-I (1-4), the known cladosporol C (5), and its new epimer, cladosporol J (6), were isolated and identified from the marine algal-derived endophytic fungus Cladosporium cladosporioides EN-399. Their structures were determined by detailed interpretation of NMR and MS data, and the absolute configurations were established on the basis of TDDFT-ECD and OR calculations. The configurational assignment of cladosporols F (1) and G (2) showed that the previously reported absolute configuration of cladosporol A and all the related cladosporols need to be revised from (4'R) to (4'S). Compounds 1-6 showed antibacterial activity against Escherichia coli, Micrococcus luteus, and Vibrio harveyi with MIC values ranging from 4 to 128 mu g/mL. Compound 3 showed significant cytotoxicity against A549, Huh7, and LM3 cell lines with IC50 values of 5.0, 1.0, and 4.1 mu M, respectively, and compound 5 showed activity against H446 cell line with IC50 value of 4.0 mu M.
DOI	10.1021/acs.joc.7b01277
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China (NSFC)[31330009]###1183; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402]###370; National Research, Development and Innovation Office[NKFI K120181]###1184; National Research, Development and Innovation Office[K112951]###1185; National Research, Development and Innovation Office[PD121020]###1186; Taishan Scholar Program from Shandong Province of China###1187; National Natural Science Foundation of China (NSFC)[31330009]; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402]; National Research, Development and Innovation Office[NKFI K120181]; National Research, Development and Innovation Office[K112951]; National Research, Development and Innovation Office[PD121020]; Taishan Scholar Program from Shandong Province of China
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000412789000003
出版者	AMER CHEMICAL SOC
引用统计	被引频次：50[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/157270
专题	实验海洋生物学重点实验室
通讯作者	Tibor Kurtan; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Hong-Lei,Li, Xiao-Ming,Attila Mandi,et al. Characterization of Cladosporols from the Marine Algal-Derived Endophytic Fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives[J]. JOURNAL OF ORGANIC CHEMISTRY,2017,82(19):9946-9954.
APA	Li, Hong-Lei.,Li, Xiao-Ming.,Attila Mandi.,Antus, Sandor.,Li, Xin.,...&Wang, Bin-Gui.(2017).Characterization of Cladosporols from the Marine Algal-Derived Endophytic Fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives.JOURNAL OF ORGANIC CHEMISTRY,82(19),9946-9954.
MLA	Li, Hong-Lei,et al."Characterization of Cladosporols from the Marine Algal-Derived Endophytic Fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives".JOURNAL OF ORGANIC CHEMISTRY 82.19(2017):9946-9954.