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| Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.) | |
Zhang, Peng1 ; Li, Xin2; Yuan, Xiao-Long1; Du, Yong-Mei1; Wang, Bin-Gui2; Zhang, Zhong-Feng1
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| 2018-12-01 | |
| 发表期刊 | MOLECULES
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| ISSN | 1420-3049 |
| 卷号 | 23期号:12页码:7 |
| 通讯作者 | Wang, Bin-Gui([email protected]) ; Zhang, Zhong-Feng([email protected]) |
| 摘要 | An endophytic fungus Arthrinium arundinis TE-3 was isolated and purified from the fresh leaves of cultivated tobacco (Nicotiana tabacum L.). Chemical investigation on this fungal strain afforded three new prenylated diphenyl ethers (1-3) as well as three known analogues (4-6). Structure elucidation of the isolated compounds was carried out by analysis of 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectra, as well as by comparison of those data with literature data. The absolute configuration of the stereogenic center at C-8 in 1 was assigned by comparison of the experimental and calculated ECD spectra. Compounds 1 and 2 showed selective antifungal activity against Mucor hiemalis with minimum inhibitory concentration (MIC) values of 8 and 4 g/mL, respectively. Compounds 5 and 6 exhibited inhibitory activity against Alteraria alternata with an MIC value of 8 g/mL. In the cytotoxic assay, 2, 5, and 6 displayed moderate in vitro cytotoxicity against the human monocytic cell line (THP-1 cell line), with IC50 values of 40.2, 28.3, and 25.9 M, respectively. This study indicated that endophytic fungi possess great potential for exploring new bioactive secondary metabolites. |
| 关键词 | tobacco-derived endophytic fungus Arthrinium arundinis Nicotiana tabacum L prenylated diphenyl ethers antifungal activity cytotoxicity |
| DOI | 10.3390/molecules23123179 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Natural Science Foundation of China[31700295]###688; Natural Science Foundation of China[31700295] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000454523000129 |
| 出版者 | MDPI |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/155962 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui; Zhang, Zhong-Feng |
| 作者单位 | 1.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China 2.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol, Inst Oceanol,Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Peng,Li, Xin,Yuan, Xiao-Long,et al. Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)[J]. MOLECULES,2018,23(12):7. |
| APA | Zhang, Peng,Li, Xin,Yuan, Xiao-Long,Du, Yong-Mei,Wang, Bin-Gui,&Zhang, Zhong-Feng.(2018).Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.).MOLECULES,23(12),7. |
| MLA | Zhang, Peng,et al."Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)".MOLECULES 23.12(2018):7. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Antifungal Prenylate（820KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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