The versatile functions of LRR-only proteins in mollusk Chlamys farreri

doi:10.1016/j.dci.2017.08.005

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	The versatile functions of LRR-only proteins in mollusk Chlamys farreri
	Wang, Mengqiang1 ; Wang, Lingling 2,3; Jia, Zhihao 1,4; Wang, Xiudan1,4 ; Yi, Qilin 3; Zhao, Lv 1,4; Song, Linsheng 2,3
	2017-12-01
发表期刊	DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号	77 页码:188-199
文章类型	Article
摘要	Leucine-rich repeat (LRR)-only proteins are involved in the innate immune responses as they mediate protein-ligand interactions. In the present study, three novel LRR-only proteins, CfLRRop-4, CfLRRop-5 and CfLRRop-6, were identified and characterized from Zhikong scallop Chlamys farreri. They all contained LRR motifs with consensus signature sequences of LxxLxLxxNxL or LxxLxLxxCxxL. All the mRNA transcripts of three CfLRRops were high abundant in hepatopancreas, gills and gonads, and their mRNA transcripts in hemocytes could respond to the stimulations of different microbes, including Vibrio anguillarum, Micrococcus luteus and Pichia pastoris. These three CfLRRops exhibited similar ligand binding and recognition characteristics as Toll-like receptors (TLRs) and NOD-like receptors (NLRs). The immune effectors, including tumor necrosis factor alpha, superoxide dismutase, catalase and lysozyme, varied significantly after the scallops were stimulated by recombinant LRR-only proteins. All these results indicated that LRR-only proteins are functionally differentiated and exhibit different immunomodulation activities on various downstream immune effectors. (C) 2017 Elsevier Ltd. All rights reserved.
关键词	Immunomodulation Innate Immunity Pattern Recognition Scallop
DOI	10.1016/j.dci.2017.08.005
收录类别	SCI
语种	英语
WOS记录号	WOS:000413387100021
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/143238
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 3.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol & Dis Contro, 52 Heishijiao St, Dalian 116023, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Wang, Mengqiang,Wang, Lingling,Jia, Zhihao,et al. The versatile functions of LRR-only proteins in mollusk Chlamys farreri[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2017,77:188-199.
APA	Wang, Mengqiang.,Wang, Lingling.,Jia, Zhihao.,Wang, Xiudan.,Yi, Qilin.,...&Song, Linsheng.(2017).The versatile functions of LRR-only proteins in mollusk Chlamys farreri.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,77,188-199.
MLA	Wang, Mengqiang,et al."The versatile functions of LRR-only proteins in mollusk Chlamys farreri".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 77(2017):188-199.

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