The sea cucumber genome provides insights into morphological evolution and visceral regeneration

doi:10.1371/journal.pbio.2003790

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	The sea cucumber genome provides insights into morphological evolution and visceral regeneration
	Zhang, Xiaojun 1,2; Sun, Lina 1,2; Yuan, Jianbo 1,2; Sun, Yamin 3; Gao, Yi 1,2; Zhang, Libin 1,2; Li, Shihao 1,2; Dai, Hui 3; Hamel, Jean-Francois 4; Liu, Chengzhang 1,2; Yu, Yang1,2 ; Liu, Shilin 1,2; Lin, Wenchao 3; Guo, Kaimin 3; Jin, Songjun 1,2; Xu, Peng5 ; Storey, Kenneth B.6; Huan, Pin1,2 ; Zhang, Tao1,2 ; Zhou, Yi1,2 ; Zhang, Jiquan 1,2; Lin, Chenggang 1,2; Li, Xiaoni 1,7; Xing, Lili1,7 ; Huo, Da 1,7; Sun, Mingzhe1,7 ; Wang, Lei 8; Mercier, Annie 9; Li, Fuhua 1,2; Yang, Hongsheng1,2 ; Xiang, Jianhai1,2
	2017-10-01
发表期刊	PLOS BIOLOGY
卷号	15 期号:10
文章类型	Article
摘要	Apart from sharing common ancestry with chordates, sea cucumbers exhibit a unique morphology and exceptional regenerative capacity. Here we present the complete genome sequence of an economically important sea cucumber, A. japonicus, generated using Illumina and PacBio platforms, to achieve an assembly of approximately 805 Mb (contig N50 of 190 Kb and scaffold N50 of 486 Kb), with 30,350 protein-coding genes and high continuity. We used this resource to explore key genetic mechanisms behind the unique biological characters of sea cucumbers. Phylogenetic and comparative genomic analyses revealed the presence of marker genes associated with notochord and gill slits, suggesting that these chordate features were present in ancestral echinoderms. The unique shape and weak mineralization of the sea cucumber adult body were also preliminarily explained by the contraction of biomineralization genes. Genome, transcriptome, and proteome analyses of organ regrowth after induced evisceration provided insight into the molecular underpinnings of visceral regeneration, including a specific tandem-duplicated prostatic secretory protein of 94 amino acids (PSP94)-like gene family and a significantly expanded fibrinogen-related protein (FREP) gene family. This high-quality genome resource will provide a useful framework for future research into biological processes and evolution in deuterostomes, including remarkable regenerative abilities that could have medical applications. Moreover, the multiomics data will be of prime value for commercial sea cucumber breeding programs.
DOI	10.1371/journal.pbio.2003790
收录类别	SCI
语种	英语
WOS记录号	WOS:000414060400012
引用统计	被引频次：189[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/143042
专题	实验海洋生物学重点实验室海洋生态与环境科学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol & Marine Ecol & Environm, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol & Marine Ecol & Envi, Qingdao, Peoples R China 3.Tianjin Biochip Corp, Tianjin, Peoples R China 4.SEVE, Portugal Cove St Philips, NF, Canada 5.Xiamen Univ, Coll Ocean & Earth Sci, Xiamen, Peoples R China 6.Carleton Univ, Dept Biol, Ottawa, ON, Canada 7.Univ Chinese Acad Sci, Beijing, Peoples R China 8.Nankai Univ, Coll Life Sci, Tianjin, Peoples R China 9.Mem Univ, Dept Ocean Sci, St John, NF, Canada
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Zhang, Xiaojun,Sun, Lina,Yuan, Jianbo,et al. The sea cucumber genome provides insights into morphological evolution and visceral regeneration[J]. PLOS BIOLOGY,2017,15(10).
APA	Zhang, Xiaojun.,Sun, Lina.,Yuan, Jianbo.,Sun, Yamin.,Gao, Yi.,...&Xiang, Jianhai.(2017).The sea cucumber genome provides insights into morphological evolution and visceral regeneration.PLOS BIOLOGY,15(10).
MLA	Zhang, Xiaojun,et al."The sea cucumber genome provides insights into morphological evolution and visceral regeneration".PLOS BIOLOGY 15.10(2017).

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文件名称/大小	文献类型	版本类型	开放类型	使用许可
The sea cucumber gen（11697KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览