| Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L) | |
Meng, Lingjie1,2 ; Du, Yishuai1; Liu, Pengfei1,2; Li, Xian1; Liu, Ying3
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| 2017-05-01 | |
| 发表期刊 | FISH & SHELLFISH IMMUNOLOGY
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| 卷号 | 64页码:260-269 |
| 文章类型 | Article |
| 摘要 | Quorum sensing is a bacterial density dependent communication system, which regarded to regulate cooperative behaviors of community and mediated by extracellular signal molecules named autoinducers (Al). Among various signals, autoinducer-2 (AI-2) is believed to be the messengers inter species and produced by LuxS. For Aeromonas salmonicida (A. salmonicida), an opportunistic pathogen to many cold-water teleost, little information has been known about the function of AI-2 and LuxS. Therefore, our aim was to preliminarily clarify the function of LuxS in A. salmonicida. The consequences demonstrated that wild type A. salmonicida exhibited Al-2 activity and luxS defective mutant strain fail to produce Al-2 signals. Furthermore, it was suggested that luxS deficiency could impact bacterial morphology, surface properties and virulence dramatically. Challenge experiment showed a tendency that immune factors expressed earlier when Atlantic salmon was infected with AluxS strain. Overall, we hypothesis that Al-2 quorum sensing could regulate the expression of A-layer protein coding gene vapA, and then influence bacterial survival ability when suffered from attack of the host immune system. Though additional studies are warranted, our study will supply a new thinking to control the damage caused by A. salmonicida. (C) 2017 Elsevier Ltd. All rights reserved. |
| 关键词 | Quorum Sensing Ai-2 Luxs Aeromonas Salmonicida Virulence Surface Property A-layer Innate Immnuity Salmo Solar l |
| DOI | 10.1016/j.fsi.2017.03.009 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000401217900028 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/136852 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Dalian Ocean Univ, Dalian 116023, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Meng, Lingjie,Du, Yishuai,Liu, Pengfei,et al. Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)[J]. FISH & SHELLFISH IMMUNOLOGY,2017,64:260-269. |
| APA | Meng, Lingjie,Du, Yishuai,Liu, Pengfei,Li, Xian,&Liu, Ying.(2017).Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L).FISH & SHELLFISH IMMUNOLOGY,64,260-269. |
| MLA | Meng, Lingjie,et al."Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)".FISH & SHELLFISH IMMUNOLOGY 64(2017):260-269. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Involvement of LuxS （2071KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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