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CD94 of tongue sole Cynoglossus semilaevis binds a wide arrange of bacteria and possesses antibacterial activity
Li, Xue-peng1,2,3; Hu, Yong-hua1,2
2016-11-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号58页码:641-649
文章类型Article
摘要In this study, we examined the expression patterns and the functions of the tongue sole Cynoglossus semilaevis CD94, CsCD94. CsCD94 is composed of 209 amino acid residues and shares 43.0-50.2% overall identities with known teleost CD94 sequence. CsCD94 has a C-type lectin-like domain. Expression of CsCD94 occurred in multiple tissues and was upregulated during bacterial infection. Recombinant CsCD94 (rCsCD94) exhibited apparent binding and agglutinating activities against both Gram-positive and Gram-negative bacteria in a Ca2+-dependent manner. Treatment of bacteria with rCsCD94 enhanced phagocytosis of the bacteria by peripheral blood leukocytes. Furthermore, incubation of rCsCD94 with bacteria reduced the survival of the bacteria in vitro. Taken together, these results indicate that rCsCD94 is a key factor in the bactericidal and phagocytic effects of tongue sole, and reveal for the first time an essential role of fish CD94 in antibacterial immunity, thereby adding insight into the function of CD94. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Cd94 Cynoglossus Semilaevis Agglutination Phagocytosis Antibacterial
DOI10.1016/j.fsi.2016.10.005
收录类别SCI
语种英语
WOS记录号WOS:000387523100074
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136199
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位中国科学院海洋研究所
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Li, Xue-peng,Hu, Yong-hua. CD94 of tongue sole Cynoglossus semilaevis binds a wide arrange of bacteria and possesses antibacterial activity[J]. FISH & SHELLFISH IMMUNOLOGY,2016,58:641-649.
APA Li, Xue-peng,&Hu, Yong-hua.(2016).CD94 of tongue sole Cynoglossus semilaevis binds a wide arrange of bacteria and possesses antibacterial activity.FISH & SHELLFISH IMMUNOLOGY,58,641-649.
MLA Li, Xue-peng,et al."CD94 of tongue sole Cynoglossus semilaevis binds a wide arrange of bacteria and possesses antibacterial activity".FISH & SHELLFISH IMMUNOLOGY 58(2016):641-649.
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