Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Genetic diversity of the sulfotransferase-like gene and one nonsynonymous SNP associated with growth traits of clam, Meretrix meretrix | |
Wang, Chao1,2; You, Yanan1,2; Wang, Hongxia1; Liu, Baozhong1 ; Liu, BZ (reprint author), Chinese Acad Sci, Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China.
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| 2012-02-01 | |
| 发表期刊 | MOLECULAR BIOLOGY REPORTS
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| ISSN | 0301-4851 |
| 卷号 | 39期号:2页码:1323-1331 |
| 文章类型 | Article |
| 摘要 | The sulfotransferase (SULT) is an important factor in phase II metabolism. Three single nucleotide polymorphisms (SNPs; MmeSUl-696, MmeSUl-714 and MmeSUl-806) were discovered in a SULT-like gene of Meretrix meretrix. A modified allele-specific PCR detection assay was developed to perform polymorphism analysis of the three SNPs in two families and two populations of M. meretrix. Results showed that the genotype of the three SNPs is accordance to the expected Mendelian segregation ratios and conforms to Hardy-Weinberg Equilibrium (HWE) in families and populations, respectively. Moreover, sampled clams (n = 151) from the two populations were tested for the associations between SNPs and growth traits. The single SNP association analysis indicated MmeSUl-806 significantly (P < 0.05) correlated with growth traits of M. meretrix. A further haplotype-trait association analysis confirmed that the three SNPs were in linkage disequilibrium and showed that the haplotype TTG and TCG associated with low growth in the two populations, respectively, which supported that MmeSUl-806 was a growth related marker. This study suggested SULT gene might be a candidate gene related to growth in bivalves and MmeSUl-806 could be a gene marker in linkage map construction and breeding programs of M. meretrix. |
| 关键词 | Meretrix Meretrix Single Nucleotide Polymorphism Sulfotransferase Growth Traits Association Study |
| 学科领域 | Biochemistry & Molecular Biology |
| DOI | 10.1007/s11033-011-0865-4 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000298751300064 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/12333 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Liu, BZ (reprint author), Chinese Acad Sci, Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Chao,You, Yanan,Wang, Hongxia,et al. Genetic diversity of the sulfotransferase-like gene and one nonsynonymous SNP associated with growth traits of clam, Meretrix meretrix[J]. MOLECULAR BIOLOGY REPORTS,2012,39(2):1323-1331. |
| APA | Wang, Chao,You, Yanan,Wang, Hongxia,Liu, Baozhong,&Liu, BZ .(2012).Genetic diversity of the sulfotransferase-like gene and one nonsynonymous SNP associated with growth traits of clam, Meretrix meretrix.MOLECULAR BIOLOGY REPORTS,39(2),1323-1331. |
| MLA | Wang, Chao,et al."Genetic diversity of the sulfotransferase-like gene and one nonsynonymous SNP associated with growth traits of clam, Meretrix meretrix".MOLECULAR BIOLOGY REPORTS 39.2(2012):1323-1331. |
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