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A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma
Wang, Cuicui1,2; Liu, Ming1; Cheng, Linyou1,2; Wei, Jianteng1,2; Wu, Ning1,2; Zheng, Lanhong1; Lin, Xiukun1,3; Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
2012-04-01
发表期刊EXPERIMENTAL BIOLOGY AND MEDICINE
ISSN1535-3702
卷号237期号:4页码:442-450
文章类型Article
摘要A novel polypeptide (Mere15) was purified from Meretrix meretrix Linnaeus by ammonium sulfate fractionation, ion exchange, gel filtration and reversed phase chromatography. Mere15 exhibited selective cytotoxicity to several human cancer cells. In vivo study showed that Mere15 significantly suppressed the growth of human lung adenocarcinoma A549 xenograft in nude mice. The mechanism was associated with a G(2)/M phase arrest followed by apoptosis, including membrane blebbing, loss of mitochondrial membrane potential, externalization of phosphatidylserine, chromosome condensation and DNA fragmentation. Western blot analysis showed that the intrinsic pathway was involved in Mere15-induced apoptosis. These results suggest that Mere15 may have therapeutic potential for the treatment of non-small-cell lung carcinoma.
关键词Meretrix Meretrix Linnaeus Antitumor Polypeptide Non-small-cell Lung Carcinoma g(2)/m Phase Arrest Apoptosis
学科领域Medicine, Research & Experimental
DOI10.1258/ebm.2012.011337
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000304515100013
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被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/12265
专题实验海洋生物学重点实验室
通讯作者Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
第一作者单位实验海洋生物学重点实验室
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Wang, Cuicui,Liu, Ming,Cheng, Linyou,et al. A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2012,237(4):442-450.
APA Wang, Cuicui.,Liu, Ming.,Cheng, Linyou.,Wei, Jianteng.,Wu, Ning.,...&Lin, XK .(2012).A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma.EXPERIMENTAL BIOLOGY AND MEDICINE,237(4),442-450.
MLA Wang, Cuicui,et al."A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma".EXPERIMENTAL BIOLOGY AND MEDICINE 237.4(2012):442-450.
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