Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection | |
| Chi, Heng1,2; Sun, Li1,2 | |
| 2016-03-01 | |
| 发表期刊 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| 卷号 | 56期号:2016页码:7-12 |
| 文章类型 | Article |
| 摘要 | Neutrophils constitute an essential part of the innate immune system. Recently, neutrophils have been found to produce a complex extracellular structure called neutrophil extracellular traps (NETs) that capture bacteria, fungi, and parasites. In fish, a few studies on NETs production have been reported, however, the function of fish NETs is unknown. In this study, we examined the ability of turbot (Scophthalmus maximus) neutrophils to produce NETs and investigated the effect of turbot NETs on bacterial infection. We found that upon lipopolysaccharides treatment, turbot head kidney neutrophils produced typical NETs structures that contained DNA and histones. Bacteria treatment also induced production of NETs, which in turn entrapped the bacterial cells and inhibited bacterial replication. Furthermore, when introduced into turbot, NETS-trapped bacteria exhibited significantly weakened ability of tissue dissemination and colonization. These results indicate for the first time that teleost NETs possess apparent antibacterial effect both in vitro and in vivo. (C) 2015 Elsevier Ltd. All rights reserved. |
| 关键词 | Neutrophil Extracellular Trap Scophthalmus Maximus Antibacterial Innate Immune Defense |
| DOI | 10.1016/j.dci.2015.11.005 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000369196900002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/112430 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Chi, Heng,Sun, Li. Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,56(2016):7-12. |
| APA | Chi, Heng,&Sun, Li.(2016).Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,56(2016),7-12. |
| MLA | Chi, Heng,et al."Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 56.2016(2016):7-12. |
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| Neutrophils of Scoph（1729KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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