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Small Molecule SHP2 Inhibitor LXQ-217 affects Lung Cancer Cell Proliferation in Vitro and in Vivo 期刊论文
CHEMISTRY & BIODIVERSITY, 2024, 页码: 11
作者:  Sun, Hao;  Bai, Xiaoyi;  Zhang, Yiting;  Gao, Yanan;  Dai, Jiajia;  Xing, Pan;  Zhu, Jiqiang;  Liu, Ruihua;  Wang, Zemin;  Li, Xiangqian
收藏  |  浏览/下载：69/0  |  提交时间：2024/06/04
Anti-tumor  SHP2  Orthosteric inhibitor  Apoptosis  Bromophenol  
Binding properties of marine bromophenols with human protein tyrosine phosphatase 1B: Molecular docking, surface plasmon resonance and cellular insulin resistance study 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 163, 页码: 200-208
作者:  Luo, Jiao;  Zhang, Renshuai;  Wang, Xuehe;  Hou, Zhanhui;  Guo, Shuju;  Jiang, Bo
Adobe PDF(3013Kb)  |  收藏  |  浏览/下载：250/0  |  提交时间：2021/04/12
PTP1B  Bromophenol  Molecular docking  Surface plasmon resonance  
Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:  Luo, Jiao;  Zheng, Meiling;  Jiang, Bo;  Li, Chao;  Guo, Shuju;  Wang, Lijun;  Li, Xiangqian;  Yu, Rilei;  Shi, Dayong
Adobe PDF(42653Kb)  |  收藏  |  浏览/下载：421/0  |  提交时间：2020/09/29
bromophenol  PTP1B inhibitor  selectivity  cell permeability  oral bioavailability  
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
作者:  Wang, Lijun;  Guo, Chuanlong;  Li, Xiuxue;  Yu, Xuemin;  Li, Xiangqian;  Xu, Kuo;  Jiang, Bo;  Jia, Xiaoling;  Li, Chao;  Shi, Dayong
Adobe PDF(4835Kb)  |  收藏  |  浏览/下载：451/0  |  提交时间：2019/08/29
Bromophenol-thiazolylhydrazone hybrids  Synthesis  Multifunctional agents  eIF4E/eIF4G interaction  Autophagy  ROS  
BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway 期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 17, 期号: 5, 页码: 3848-3858
作者:  Guo, Chuanlong;  Wang, Lijun;  Zhao, Yue;  Jiang, Bo;  Luo, Jiao;  Shi, Dayong
Adobe PDF(2683Kb)  |  收藏  |  浏览/下载：331/0  |  提交时间：2019/08/28
bromophenol  apoptosis  autophagy  phosphoinositide 3-kinase  protein kinase B  mechanistic target of rapamycin signaling  reactive oxygen species  
Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae) 期刊论文
BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2018, 卷号: 81, 页码: 42-44
作者:  Xu, Kuo;  Guo, Shuju;  Jia, Xiaoling;  Li, Xiang;  Shi, Dayong
Adobe PDF(298Kb)  |  收藏  |  浏览/下载：341/0  |  提交时间：2019/05/15
Leathesia nana  Chordariaceae  Bromophenol  Chemotaxonomy  PTP1B  
A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway 期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 2, 页码: 13
作者:  Guo, Chuan-Long;  Wang, Li-Jun;  Zhao, Yue;  Liu, Hua;  Li, Xiang-Qian;  Jiang, Bo;  Luo, Jiao;  Guo, Shu-Ju;  Wu, Ning;  Shi, Da-Yong
Adobe PDF(5208Kb)  |  收藏  |  浏览/下载：437/0  |  提交时间：2019/08/21
bromophenol  molecular mechanisms  apoptosis  cell cycle  PI3K  Akt  p38  ERK  ROS  human lung cancer  
Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation 期刊论文
MARINE DRUGS, 2017, 卷号: 15, 期号: 11, 页码: 18
作者:  Wang, Li-Jun;  Guo, Chuan-Long;  Li, Xiang-Qian;  Wang, Shuai-Yu;  Jiang, Bo;  Zhao, Yue;  Luo, Jiao;  Xu, Kuo;  Liu, Hua;  Guo, Shu-Ju;  Wu, Ning;  Shi, Da-Yong
收藏  |  浏览/下载：400/0  |  提交时间：2019/07/15
bromophenol hybrids  anticancer  structure-activity relationships  ROS  apoptotic pathway  
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 134, 页码: 24-33
作者:  Zhang, Renshuai;  Yu, Rilei;  Xu, Qi;  Li, Xiangqian;  Luo, Jiao;  Jiang, Bo;  Wang, Lijun;  Guo, Shuju;  Wu, Ning;  Shi, Dayong
Adobe PDF(3126Kb)  |  收藏  |  浏览/下载：327/0  |  提交时间：2017/07/10
Ptp1b  Bromophenol  Saccharide  Selectivity  Permeability  
Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 64, 页码: 129-136
作者:  Jiang, Bo;  Guo, Shuju;  Shi, Dayong;  Guo, Chao;  Wang, Tao;  Shi, DY
Adobe PDF(1213Kb)  |  收藏  |  浏览/下载：387/1  |  提交时间：2014/07/17
Type 2 Diabetes Mellitus  Protein Tyrosine Phosphatase 1b  Bromophenol  Anti-diabetic Activities