Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems | |
| Qi, Xin1; Liu, Ge2; Qiu, Lin3; Lin, Xiukun4; Liu, Ming1 | |
| 2015-10-01 | |
| 发表期刊 | BIOMEDICINE & PHARMACOTHERAPY
 |
| 卷号 | 75期号:2015页码:58-66 |
| 文章类型 | Article |
| 摘要 | Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol compound derived from marine algae. Our previous reports have shown that BDDE possessed anticancer activity in vitro. However, its antiangiogenesis activity and possible mechanisms remain unclear. The present study demonstrated that BDDE displayed in vitro antiangiogenesis capabilities by significantly inhibiting HUVEC cells proliferation, migration, and tube formation, without any effect on the preformed vascular tube. Western blot analysis revealed that BDDE decreased the protein level of VEGF and VEGFR but not that of EGFR, FGFR, and IGFR. In addition, BDDE inactivated the VEGF downstream signaling molecules including mTOR and Src, whereas activated Akt and ERK. Moreover, BDDE blocked subintestinal vessel formation in zebrafish embryos in vivo and showed toxicity under high concentrations of BDDE. The results of this present study indicated that BDDE, which has unique chemical structure different from current antiangiogenesis agents, could be used as a potential drug candidate for cancer prevention and therapy. (C) 2015 Elsevier Masson SAS. All rights reserved. |
| 关键词 | Antiangiogenesis Bis(2 Zebrafish 3-dibromo-4 Vegf 5-dihydroxybenzyl) Ether Vegfr |
| DOI | 10.1016/j.biopha.2015.08.033 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367509300009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/86651 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 4.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Xin,Liu, Ge,Qiu, Lin,et al. Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems[J]. BIOMEDICINE & PHARMACOTHERAPY,2015,75(2015):58-66. |
| APA | Qi, Xin,Liu, Ge,Qiu, Lin,Lin, Xiukun,&Liu, Ming.(2015).Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems.BIOMEDICINE & PHARMACOTHERAPY,75(2015),58-66. |
| MLA | Qi, Xin,et al."Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems".BIOMEDICINE & PHARMACOTHERAPY 75.2015(2015):58-66. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Marine bromophenol b（2610KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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