| Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety | |
| Wang, Shuai-Yu; Wang, Li-Jun; Jiang, Bo; Wu, Ning; Li, Xiang-Qian; Luo, Jiao; Wang, Bao-Cheng; Zhang, Ren-Shuai; Xu, Qi; Shi, Da-Yong | |
| 2015 | |
| 发表期刊 | RSC Advances
 |
| 卷号 | 5期号:111页码:91795-91801 |
| 文章类型 | Article |
| 摘要 | A series of novel fluorinated anticancer agents containing the indolin-2-one moiety were designed, synthesized and evaluated for their anticancer activities in vitro. Among them, compounds 6, 7, 9, 12 and 13 showed potent activities against the tested human cancer cell lines. Notably, compound 6 showed significant activities against A549, Bel7402, HepG2, HCT116 and HeLa cancer cell lines, which were comparable to those of sunitinib. Further study on its mechanisms demonstrated that compound 6 can be used as a potential anticancer agent for inhibiting proliferation and inducing apoptosis of HepG2 cells, along with inhibiting angiogenesis of HUVECs. |
| DOI | 10.1039/c5ra19617e |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364057000084 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/82292 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Shuai-Yu,Wang, Li-Jun,Jiang, Bo,et al. Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety[J]. RSC Advances,2015,5(111):91795-91801. |
| APA | Wang, Shuai-Yu.,Wang, Li-Jun.,Jiang, Bo.,Wu, Ning.,Li, Xiang-Qian.,...&Shi, Da-Yong.(2015).Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety.RSC Advances,5(111),91795-91801. |
| MLA | Wang, Shuai-Yu,et al."Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety".RSC Advances 5.111(2015):91795-91801. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Synthesis and biolog（1588KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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