| The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis) | |
| Meng, Xiaolin1; Tian, Xue1; Nie, Guoxing1; Wang, Junli1; Liu, Mei2; Jiang, Keyong2; Wang, Baojie2; Guo, Qianqian1; Huang, Jianrong1; Wang, Lei2 | |
| 2015-10-01 | |
| 发表期刊 | FISH & SHELLFISH IMMUNOLOGY
 |
| 卷号 | 46期号:2页码:161-167 |
| 文章类型 | Article |
| 摘要 | The present study was conducted to elucidate the effects of copper exposure on the immune system and lipid metabolism of the Japanese scallop, Mizuhopecten yessoensts. Transcriptional levels of differentially expressed genes (DEGs)in M. yessoensis digestive gland tissue were analyzed using the deep-sequencing platform Illumina HiSeq (TM) 2000. In total, 841 and 877 genes were identified as significantly up- or down-regulated, respectively. In addition, significant enrichment analysis identified 3 gene ontology terms and 15 pathways involved in the response to copper exposure. Analysis of transcripts related to the immune response revealed a complex pattern of innate recognition receptors, including toll-like receptors, NOD-like receptors and downstream pathway effectors, including those involved in apoptosis. Furthermore, genomic analysis revealed that genes involved in extracellular matrix (ECM)-receptor interactions were enriched in Cu-exposed scallop glands. These results will provide a resource for subsequent gene expression studies regarding heavy metal exposure and the identification of copper-sensitive biomarkers for the aquaculture of M. yessoensis. (C) 2015 Elsevier Ltd. All rights reserved. |
| 关键词 | Mizuhopecten Yessoensis Digestive Gland Copper Deep-sequencing |
| DOI | 10.1016/j.fsi.2015.05.022 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000363071200001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/73940 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Henan Normal Univ, Coll Fisheries, Xinxiang 453007, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, R&D Ctr Marine, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Xiaolin,Tian, Xue,Nie, Guoxing,et al. The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)[J]. FISH & SHELLFISH IMMUNOLOGY,2015,46(2):161-167. |
| APA | Meng, Xiaolin.,Tian, Xue.,Nie, Guoxing.,Wang, Junli.,Liu, Mei.,...&Wang, Lei.(2015).The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis).FISH & SHELLFISH IMMUNOLOGY,46(2),161-167. |
| MLA | Meng, Xiaolin,et al."The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)".FISH & SHELLFISH IMMUNOLOGY 46.2(2015):161-167. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| The transcriptomic r（982KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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