| The preparation and antioxidant activity of the sulfanilamide derivatives of chitosan and chitosan sulfates | |
Zhong, Zhimei; Ji, Xia; Xing, Ronge ; Liu, Song; Guo, Zhanyong; Chen, Xiaolin; Li, Pengcheng
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| 2007-06-01 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY
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| ISSN | 0968-0896 |
| 卷号 | 15期号:11页码:3775-3782 |
| 文章类型 | Article |
| 摘要 | Chitosan (CS) and chitosan sulfates (CSS) with different molecular weight (Mw) were reacted with 4-acetamidobenzene sulfonyl chloride to obtain sulfanilamide derivatives of chitosan and chitosan sulfates (LSACS, HSACS, LSACSS, HSACSS). The preparation conditions such as different reaction time, temperature, solvent, and the molar ratio of reaction materials are discussed in this paper. Their structures were characterized by FTIR spectroscopy and elemental analyses. The antioxidant activities of the derivatives were investigated employing various established in vitro systems, such as hydroxyl-radical (OH) superoxide anion (O(2)(center dot-)) scavenging and reducing power. All kinds of the compounds (HCS, LCS, HCSS, LCSS, HSACS, LSACS, HSACSS, LSACSS) showed stronger scavenging activity on hydroxyl radical than ascorbic acid (Vc). The inhibitory activities of the derivatives toward superoxide radical by the PMS-NADH system were obvious. The experiment showed that the superoxide radical scavenging effect of sulfanilamide derivatives of chitosan and chitosan sulfates was stronger than that of original CS and CSS. All of the derivatives were efficient in the reducing power. The results indicated that the sulfanilamide group were grafted on CS and CSS increased the reducing power of them obviously. (c) 2007 Elsevier Ltd. All rights reserved.; Chitosan (CS) and chitosan sulfates (CSS) with different molecular weight (Mw) were reacted with 4-acetamidobenzene sulfonyl chloride to obtain sulfanilamide derivatives of chitosan and chitosan sulfates (LSACS, HSACS, LSACSS, HSACSS). The preparation conditions such as different reaction time, temperature, solvent, and the molar ratio of reaction materials are discussed in this paper. Their structures were characterized by FTIR spectroscopy and elemental analyses. The antioxidant activities of the derivatives were investigated employing various established in vitro systems, such as hydroxyl-radical (OH) superoxide anion (O-2(center dot-)) scavenging and reducing power. All kinds of the compounds (HCS, LCS, HCSS, LCSS, HSACS, LSACS, HSACSS, LSACSS) showed stronger scavenging activity on hydroxyl radical than ascorbic acid (Vc). The inhibitory activities of the derivatives toward superoxide radical by the PMS-NADH system were obvious. The experiment showed that the superoxide radical scavenging effect of sulfanilamide derivatives of chitosan and chitosan sulfates was stronger than that of original CS and CSS. All of the derivatives were efficient in the reducing power. The results indicated that the sulfanilamide group were grafted on CS and CSS increased the reducing power of them obviously. (c) 2007 Elsevier Ltd. All rights reserved. |
| 关键词 | Sulfanilamide Derivatives Of Chitosan And Chitosan Sulfates Synthesis Antioxidant Activity |
| 学科领域 | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
| DOI | 10.1016/j.bmc.2007.03.036 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000246649000019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/6134 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhong, Zhimei,Ji, Xia,Xing, Ronge,et al. The preparation and antioxidant activity of the sulfanilamide derivatives of chitosan and chitosan sulfates[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2007,15(11):3775-3782. |
| APA | Zhong, Zhimei.,Ji, Xia.,Xing, Ronge.,Liu, Song.,Guo, Zhanyong.,...&Li, Pengcheng.(2007).The preparation and antioxidant activity of the sulfanilamide derivatives of chitosan and chitosan sulfates.BIOORGANIC & MEDICINAL CHEMISTRY,15(11),3775-3782. |
| MLA | Zhong, Zhimei,et al."The preparation and antioxidant activity of the sulfanilamide derivatives of chitosan and chitosan sulfates".BIOORGANIC & MEDICINAL CHEMISTRY 15.11(2007):3775-3782. |
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