| Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell | |
| Shi Dayong1; Xu Feng4; He Juan4; Shi Jiangong2,3; Fan Xiao1; Han Lijun1 | |
| 2008 | |
| 发表期刊 | ACTA OCEANOLOGICA SINICA
 |
| ISSN | 0253-505X |
| 卷号 | 27期号:1页码:147-151 |
| 文章类型 | Article |
| 摘要 | Chemical investigation of the ethanol extract of the marine green alga Chaetomorpha basiretorsa Setchell led to the isolation of a new sterol stigmast-4,28-dien-3 alpha 6 beta-diol 1 in addition to the five known sterols of beta-lawsaritol 2, saringosterol 3, 24-hydroperoxy-24-vinyl - cholesterol 4, beta-stigmasterol 5, 29-hydroxystigmasta-5, 24(28) -dien-3 beta-ol 6. Compounds were isolated by normal phase silica gel and Sephadex LH - 20 gel colum chromatography, reverse phase HPLC and recrystalization. Their structures were elucidated by spectroscopic methods including MS, IR 1D/2D NMR and X-ray analysis. Cytotoxicity of compounds was screened by using the standard WIT method. All these compounds were isolated from the green alga Chaetomorpha basiretorsa Setchell for the first time and they were inactive (50% inhibitory concentration was greater than 10 mu g /cm(3)) against KB, Bel -7402, PC - 3M, Ketr 3 and MCF - 7 cell lines.; Chemical investigation of the ethanol extract of the marine green alga Chaetomorpha basiretorsa Setchell led to the isolation of a new sterol stigmast-4,28-dien-3 alpha 6 beta-diol 1 in addition to the five known sterols of beta-lawsaritol 2, saringosterol 3, 24-hydroperoxy-24-vinyl - cholesterol 4, beta-stigmasterol 5, 29-hydroxystigmasta-5, 24(28) -dien-3 beta-ol 6. Compounds were isolated by normal phase silica gel and Sephadex LH - 20 gel colum chromatography, reverse phase HPLC and recrystalization. Their structures were elucidated by spectroscopic methods including MS, IR 1D/2D NMR and X-ray analysis. Cytotoxicity of compounds was screened by using the standard WIT method. All these compounds were isolated from the green alga Chaetomorpha basiretorsa Setchell for the first time and they were inactive (50% inhibitory concentration was greater than 10 mu g /cm(3)) against KB, Bel -7402, PC - 3M, Ketr 3 and MCF - 7 cell lines. |
| 关键词 | Green Alga Sterol X-ray Crystal Structure |
| 学科领域 | Oceanography |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000254674200017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/6084 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 3.Beijing Union Med Coll, Beijing 100050, Peoples R China 4.Qingdao Univ, Affiliated Hosp, Coll Med, Qingdao 266003, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Shi Dayong,Xu Feng,He Juan,et al. Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell[J]. ACTA OCEANOLOGICA SINICA,2008,27(1):147-151. |
| APA | Shi Dayong,Xu Feng,He Juan,Shi Jiangong,Fan Xiao,&Han Lijun.(2008).Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell.ACTA OCEANOLOGICA SINICA,27(1),147-151. |
| MLA | Shi Dayong,et al."Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell".ACTA OCEANOLOGICA SINICA 27.1(2008):147-151. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| shi-Crystallographic（146KB） | 限制开放 | -- | 浏览 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论