Lineage-specific domain fusion in the evolution of purine nucleotide cyclases in cyanobacteria

doi:10.1007/s00239-008-9127-z

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	Lineage-specific domain fusion in the evolution of purine nucleotide cyclases in cyanobacteria
	Wu, Jinyu 1; Bai, Jie 1; Bao, Qiyu 1; Zhao, Fangqing 2,3
	2008-07-01
发表期刊	JOURNAL OF MOLECULAR EVOLUTION
ISSN	0022-2844
卷号	67 期号:1 页码:85-94
文章类型	Article
摘要	Cyclic nucleotides (both cAMP and cGMP) play extremely important roles in cyanobacteria, such as regulating heterocyst formation, respiration, or gliding. Catalyzing the formation of cAMP and cGMP from ATP and GTP is a group of functionally important enzymes named adenylate cyclases and guanylate cyclases, respectively. To understand their evolutionary patterns, in this study, we presented a systematic analysis of all the cyclases in cyanobacterial genomes. We found that different cyanobacteria had various numbers of cyclases in view of their remarkable diversities in genome size and physiology. Most of these cyclases exhibited distinct domain architectures, which implies the versatile functions of cyanobacterial cyclases. Mapping the whole set of cyclase domain architectures from diverse prokaryotic organisms to their phylogenetic tree and detailed phylogenetic analysis of cyclase catalytic domains revealed that lineage-specific domain recruitment appeared to be the most prevailing pattern contributing to the great variability of cyanobacterial cyclase domain architectures. However, other scenarios, such as gene duplication, also occurred during the evolution of cyanobacterial cyclases. Sequence divergence seemed to contribute to the origin of putative guanylate cyclases which were found only in cyanobacteria. In conclusion, the comprehensive survey of cyclases in cyanobacteria provides novel insight into their potential evolutionary mechanisms and further functional implications.; Cyclic nucleotides (both cAMP and cGMP) play extremely important roles in cyanobacteria, such as regulating heterocyst formation, respiration, or gliding. Catalyzing the formation of cAMP and cGMP from ATP and GTP is a group of functionally important enzymes named adenylate cyclases and guanylate cyclases, respectively. To understand their evolutionary patterns, in this study, we presented a systematic analysis of all the cyclases in cyanobacterial genomes. We found that different cyanobacteria had various numbers of cyclases in view of their remarkable diversities in genome size and physiology. Most of these cyclases exhibited distinct domain architectures, which implies the versatile functions of cyanobacterial cyclases. Mapping the whole set of cyclase domain architectures from diverse prokaryotic organisms to their phylogenetic tree and detailed phylogenetic analysis of cyclase catalytic domains revealed that lineage-specific domain recruitment appeared to be the most prevailing pattern contributing to the great variability of cyanobacterial cyclase domain architectures. However, other scenarios, such as gene duplication, also occurred during the evolution of cyanobacterial cyclases. Sequence divergence seemed to contribute to the origin of putative guanylate cyclases which were found only in cyanobacteria. In conclusion, the comprehensive survey of cyclases in cyanobacteria provides novel insight into their potential evolutionary mechanisms and further functional implications.
关键词	Cyanobacteria Domain Fusion Evolutionary Mechanism Purine Nucleotide Cyclase
学科领域	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
DOI	10.1007/s00239-008-9127-z
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000258088000009
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/5684
专题	实验海洋生物学重点实验室
作者单位	1.Wenzhou Med Coll, Inst Biomed Informat, Zhejiang Prov Key Lab Med Genet, Wenzhou 325000, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
推荐引用方式 GB/T 7714	Wu, Jinyu,Bai, Jie,Bao, Qiyu,et al. Lineage-specific domain fusion in the evolution of purine nucleotide cyclases in cyanobacteria[J]. JOURNAL OF MOLECULAR EVOLUTION,2008,67(1):85-94.
APA	Wu, Jinyu,Bai, Jie,Bao, Qiyu,&Zhao, Fangqing.(2008).Lineage-specific domain fusion in the evolution of purine nucleotide cyclases in cyanobacteria.JOURNAL OF MOLECULAR EVOLUTION,67(1),85-94.
MLA	Wu, Jinyu,et al."Lineage-specific domain fusion in the evolution of purine nucleotide cyclases in cyanobacteria".JOURNAL OF MOLECULAR EVOLUTION 67.1(2008):85-94.

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