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	Tongue sole (Cynoglossus semilaevis) prothymosin alpha: Cytokine-like activities associated with the intact protein and the C-terminal region that lead to antiviral immunity via Myd88-dependent and -independent pathways respectively
	Zhang, Bao-cun; Sun, Li
	2015-11-01
发表期刊	DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号	53期号:1页码:96-104
文章类型	Article
摘要	Prothymosin alpha (ProT alpha) is a small protein that in mammals is known to participate in diverse biological processes including immunomodulation. In teleost, the immunological function of ProT alpha is unknown. In the current study, we investigated the expression and function of the ProT alpha (named CsProT alpha) from the teleost fish tongue sole (Cynoglossus semilaevis). We found that CsProT alpha expression was abundant in immune relevant tissues and upregulated by megalocytivirus infection. Immunoblot detected secretion of CsProT alpha by peripheral blood leukocytes. Recombinant CsProT alpha (rCsProT alpha) as well as the C-terminal 11-residue (Ct11) were able to bind head kidney monocytes (HKM) and induce immune gene expression; however, the induction patterns caused by rCsProT alpha and Ct11 differed considerably. When introduced in vivo, rCsProT alpha and Ctll significantly reduced megalocytivirus infection in fish tissues, whereas rCsProT alpha antibody significantly promoted viral replication. Blocking of Myd88 activity abolished the virus-inhibitory effect of rCsProT alpha but not Ct11. Taken together, these results demonstrate for the first time that both the intact protein and the C-terminal segment of a teleost ProT alpha can act like cytokines and induce antiviral immunity via, however, distinct signaling pathways that differ in the requirement of Myd88. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Cynoglossus Semilaevis Prothymosin Antiviral Immunoregulation
DOI	10.1016/j.dci.2015.07.004
收录类别	SCI
语种	英语
WOS记录号	WOS:000360772900012
引用统计	被引频次：41[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/50425
专题	实验海洋生物学重点实验室
作者单位	Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Zhang, Bao-cun,Sun, Li. Tongue sole (Cynoglossus semilaevis) prothymosin alpha: Cytokine-like activities associated with the intact protein and the C-terminal region that lead to antiviral immunity via Myd88-dependent and -independent pathways respectively[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2015,53(1):96-104.
APA	Zhang, Bao-cun,&Sun, Li.(2015).Tongue sole (Cynoglossus semilaevis) prothymosin alpha: Cytokine-like activities associated with the intact protein and the C-terminal region that lead to antiviral immunity via Myd88-dependent and -independent pathways respectively.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,53(1),96-104.
MLA	Zhang, Bao-cun,et al."Tongue sole (Cynoglossus semilaevis) prothymosin alpha: Cytokine-like activities associated with the intact protein and the C-terminal region that lead to antiviral immunity via Myd88-dependent and -independent pathways respectively".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 53.1(2015):96-104.

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