Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7 '-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-Derived Fungus Penicillium adametzioides | |
Liu, Yang1,2 ; Mandi, Attila3; Li, Xiao-Ming1; Meng, Ling-Hong1,2; Kurtan, Tibor3; Wang, Bin-Gui1
| |
| 2015-06-01 | |
| 发表期刊 | MARINE DRUGS
 |
| 卷号 | 13期号:6页码:3640-3652 |
| 文章类型 | Article |
| 摘要 | Peniciadametizine A (1); a new dithiodiketopiperazine derivative possessing a unique spiro[furan-2,7'-pyrazino[1,2-b][1,2]oxazine] skeleton, together with a highly oxygenated new analogue, peniciadametizine B (2); as well as two known compounds, brasiliamide A (3); and viridicatumtoxin (4), were isolated and identified from Penicillium adametzioides AS-53, a fungus obtained from an unidentified marine sponge. The unambiguous assignment of the relative and absolute configuration for the spiro center C-2 of compound 1 was solved by the combination of NMR and ECD measurements with Density-Functional Theory (DFT) conformational analysis and Time-Dependent Density-Functional Theory-Electronic Circular Dichroism (TDDFT-ECD) calculations. The spiro[furan-2,7'-pyrazino[1,2-b][1,2]oxazine] skeleton of 1 has not been reported yet among natural products and the biosynthetic pathway for 1 and 2 was discussed. Compounds 1 and 2 showed inhibitory activity against the pathogenic fungus Alternaria brassicae. |
| 关键词 | Marine Sponge Endophytic Fungus Penicillium Adametzioides Secondary Metabolites Antifungal Activity |
| DOI | 10.3390/md13063640 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000357279900023 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/49045 |
| 专题 | 实验海洋生物学重点实验室 海洋生态与环境科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Yang,Mandi, Attila,Li, Xiao-Ming,et al. Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7 '-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-Derived Fungus Penicillium adametzioides[J]. MARINE DRUGS,2015,13(6):3640-3652. |
| APA | Liu, Yang,Mandi, Attila,Li, Xiao-Ming,Meng, Ling-Hong,Kurtan, Tibor,&Wang, Bin-Gui.(2015).Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7 '-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-Derived Fungus Penicillium adametzioides.MARINE DRUGS,13(6),3640-3652. |
| MLA | Liu, Yang,et al."Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7 '-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-Derived Fungus Penicillium adametzioides".MARINE DRUGS 13.6(2015):3640-3652. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Peniciadametizine A,（1389KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论