In vivo antitumor and immunomodulation activities of different molecular weight Lambda-Carrageenans from Chondrus ocellatus

doi:10.1016/j.phrs.2003.12.002

IOCAS-IR > 海洋生物技术研发中心

	In vivo antitumor and immunomodulation activities of different molecular weight Lambda-Carrageenans from Chondrus ocellatus
	Zhou, GF ; Sun, YP ; Xin, H ; Zhang, YN ; Li, Z ; Xu, ZH
	2004-07-01
发表期刊	PHARMACOLOGICAL RESEARCH
ISSN	1043-6618
卷号	50 期号:1 页码:47-53
文章类型	Article
摘要	lambda-Carrageenan is a sulfated galactan isolated from some red algae and have been reported to have many kinds of biological activities. lambda-Carrageenan from Chondrus ocellatus, an important economic alga in China and many other parts of the world, was degraded by microwave, and obtained five products that have different molecular weight: 650, 240, 140, 15, 9.3 kDa. Analytical results confirmed that microwave degradation might not change the chemical components and structure of polysaccharides under certain condition. In this study, tumor-inhibiting activities, weight of immune organ, nature killer cells activity, lymphocyte proliferation ratio and pathological slice of spleen and tumor cells from the control group and lambda-carrageenan-treated mice of transplanted S 180 and H22 tumor were investigated. The results indicated that the five lambda-carrageenan samples all showed antitumor and immunomodulation activities in different degree. Molecular weight of polysaccharides had notable effect on the activities. In addition, their antitumor and immunomodulation have some relevance and the five lambda-carrageenans probably inhibited tumor by means of activating the immunocompetence of the body. Among all the experiment results, samples with the highest activities are PC4 and PC5 whose molecular weight are 15 and 9.3 kDa. (C) 2003 Elsevier Ltd. All rights reserved.; lambda-Carrageenan is a sulfated galactan isolated from some red algae and have been reported to have many kinds of biological activities. lambda-Carrageenan from Chondrus ocellatus, an important economic alga in China and many other parts of the world, was degraded by microwave, and obtained five products that have different molecular weight: 650, 240, 140, 15, 9.3 kDa. Analytical results confirmed that microwave degradation might not change the chemical components and structure of polysaccharides under certain condition. In this study, tumor-inhibiting activities, weight of immune organ, nature killer cells activity, lymphocyte proliferation ratio and pathological slice of spleen and tumor cells from the control group and lambda-carrageenan-treated mice of transplanted S 180 and H22 tumor were investigated. The results indicated that the five lambda-carrageenan samples all showed antitumor and immunomodulation activities in different degree. Molecular weight of polysaccharides had notable effect on the activities. In addition, their antitumor and immunomodulation have some relevance and the five lambda-carrageenans probably inhibited tumor by means of activating the immunocompetence of the body. Among all the experiment results, samples with the highest activities are PC4 and PC5 whose molecular weight are 15 and 9.3 kDa. (C) 2003 Elsevier Ltd. All rights reserved.
关键词	Microwave Degradation Molecular Weight Lambda-carrageenan Anti-tumor Immunomodulation
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.phrs.2003.12.002
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000222038600005
引用统计	被引频次：260[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/3584
专题	海洋生物技术研发中心
作者单位	1.Acad Sinica, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Coll LaiYang Agr, Qingdao 266109, Peoples R China
推荐引用方式 GB/T 7714	Zhou, GF,Sun, YP,Xin, H,et al. In vivo antitumor and immunomodulation activities of different molecular weight Lambda-Carrageenans from Chondrus ocellatus[J]. PHARMACOLOGICAL RESEARCH,2004,50(1):47-53.
APA	Zhou, GF,Sun, YP,Xin, H,Zhang, YN,Li, Z,&Xu, ZH.(2004).In vivo antitumor and immunomodulation activities of different molecular weight Lambda-Carrageenans from Chondrus ocellatus.PHARMACOLOGICAL RESEARCH,50(1),47-53.
MLA	Zhou, GF,et al."In vivo antitumor and immunomodulation activities of different molecular weight Lambda-Carrageenans from Chondrus ocellatus".PHARMACOLOGICAL RESEARCH 50.1(2004):47-53.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
zhou-In vivo antitum（374KB）			限制开放	--	浏览