Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro

doi:10.1016/j.bmc.2004.12.022

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	Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro
	Xing, RE; Liu, S ; Guo, ZY ; Yu, HH; Wang, PB ; Li, CP ; Li, Z ; Li, PC
	2005-03-01
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY
ISSN	0968-0896
卷号	13 期号:5 页码:1573-1577
文章类型	Article
摘要	The antioxidant potency of different molecular weight (DMW) chitosan and sulfated chitosan derivatives was investigated employing various established in vitro systems, such as superoxide (O(2)(.-))/hydroxyl ((.)OH) radicals scavenging, reducing power, iron ion chelating. As expected, we obtained several satisfying results, as follows:; The antioxidant potency of different molecular weight (DMW) chitosan and sulfated chitosan derivatives was investigated employing various established in vitro systems, such as superoxide (O-2(.-))/hydroxyl ((OH)-O-.) radicals scavenging, reducing power, iron ion chelating. As expected, we obtained several satisfying results, as follows: Firstly, low molecular weight chitosan had stronger scavenging effect on O-2(.-) and (OH)-O-. than high molecular weight chitosan. For example the O-2(.-) scavenging activity of low molecular weight chitosan (9 kDa) and high molecular weight chitosan (760 kDa) were 85.86 % and 35.50 % at 1.6 mg/mL, respectively. Secondly, comparing with DMW chitosan, DMW sulfated chitosans had the stronger inhibition effect on 0(2)(.-). At 0.05 mg/mL, the scavenging activity on O-2(.-) reached 86.26 %, for low molecular weight chitosan sulfate (9 kDa), but that of low molecular weight chitosan (9 kDa) was 85.86 % at 1.6 mg/mL. As concerning chitosan and sulfated chitosan of the same molecular weight, scavenging activities of sulfated chitosan on superoxide and hydroxyl radicals were more pronounced than that of chitosan. Thirdly, low molecular weight chitosan sulfate had more effective scavenging activity on 02 and (OH)-O-. than that of high molecular weight chitosan sulfate. Fourthly, DMW chitosans and sulfated chitosans were efficient in the reducing power, especially LCTS. Their orders were found to be LCTS > CTS4 > HCTS > CTS3 > CTS2 > CTS1 > CTS. Fifthly, CTS4 showed more considerable ferrous ion-chelating potency than others. Finally, the scavenging rate and reducing power of DMW chitosan and sulfated derivatives increased with their increasing concentration. Moreover, change of DMW sulfated chitosans was the most pronounced within the experimental concentration. However, chelating effect of DMW chitosans were not concentration dependent except for CTS4 and CTS1. (C) 2004 Elsevier Ltd. All rights reserved.
关键词	Dmw Chitosans Dmw Sulfated Chitosans Radical Scavenging Effect Reducing Power Chelating Effect Comparative Relevance
学科领域	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
DOI	10.1016/j.bmc.2004.12.022
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000227251300016
引用统计	被引频次：229[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/3544
专题	海洋生物技术研发中心海洋环境工程技术研究发展中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Xing, RE,Liu, S,Guo, ZY,et al. Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2005,13(5):1573-1577.
APA	Xing, RE.,Liu, S.,Guo, ZY.,Yu, HH.,Wang, PB.,...&Li, PC.(2005).Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro.BIOORGANIC & MEDICINAL CHEMISTRY,13(5),1573-1577.
MLA	Xing, RE,et al."Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro".BIOORGANIC & MEDICINAL CHEMISTRY 13.5(2005):1573-1577.

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