| Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats | |
Li, N; Zhang, QB; Song, JM
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| 2005-03-01 | |
| 发表期刊 | FOOD AND CHEMICAL TOXICOLOGY
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| ISSN | 0278-6915 |
| 卷号 | 43期号:3页码:421-426 |
| 文章类型 | Article |
| 摘要 | Fucoidans, the sulfated polysacchrides extracted from brown algae, have been extensively studied for their diverse biological activities. However, there is no detailed report investigating the toxicity of fucoidan. In this study, the acute and subchronic (6 months) toxicity of varying levels of fucoidan extracted from Laminaria japonica was investigated in Wistar rats after oral administration. The results showed that no significant toxicological changes were observed when 300 mg/kg body weight per day fucoidan was administered to rats. But when the dose was increased to 900 and 2500 mg/kg body weight per day, the clotting time was significantly prolonged. Besides this, no other signs of toxicity were observed. Based on these results, it can be concluded that the no adverse effect level of fucoidan from L. japonica is 300 mg/kg body weight per day. (C) 2004 Elsevier Ltd. All rights reserved.; Fucoidans, the sulfated polysacchrides extracted from brown algae, have been extensively studied for their diverse biological activities. However, there is no detailed report investigating the toxicity of fucoidan. In this study, the acute and subchronic (6 months) toxicity of varying levels of fucoidan extracted from Laminaria japonica was investigated in Wistar rats after oral administration. The results showed that no significant toxicological changes were observed when 300 mg/kg body weight per day fucoidan was administered to rats. But when the dose was increased to 900 and 2500 mg/kg body weight per day, the clotting time was significantly prolonged. Besides this, no other signs of toxicity were observed. Based on these results, it can be concluded that the no adverse effect level of fucoidan from L. japonica is 300 mg/kg body weight per day. (C) 2004 Elsevier Ltd. All rights reserved. |
| 关键词 | Fucoidan Laminaria Japonica Acute/subchronic Toxicity Rats |
| 学科领域 | Food Science & Technology ; Toxicology |
| DOI | 10.1016/j.fct.2004.12.001 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000226962400004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/3516 |
| 专题 | 海洋生物技术研发中心 海洋生态与环境科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, N,Zhang, QB,Song, JM. Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2005,43(3):421-426. |
| APA | Li, N,Zhang, QB,&Song, JM.(2005).Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats.FOOD AND CHEMICAL TOXICOLOGY,43(3),421-426. |
| MLA | Li, N,et al."Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats".FOOD AND CHEMICAL TOXICOLOGY 43.3(2005):421-426. |
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