Early expressed genes showing a dichotomous developing pattern in the lancelet embryo

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	Early expressed genes showing a dichotomous developing pattern in the lancelet embryo
	Yasui, K ; Saiga, H ; Wang, Y; Zhang, PJ ; Semba, I
	2001-04-01
发表期刊	DEVELOPMENT GROWTH & DIFFERENTIATION
ISSN	0012-1592
卷号	43 期号:2 页码:185-194
文章类型	Article
摘要	Lancelets (amphioxus), although showing the most similar anatomical features to vertebrates, never develop a vertebrate-like head but rather several structures specific to this animal. The lancelet anatomical specificity seems to be traceable to early developmental stages, such as the vertebrate dorsal and anterior-posterior determinations. The BMP and Wnt proteins play important roles in establishing the early basis of the dorsal structures and the head in vertebrates. The early behavior of BMP and Wnt may be also related to the specific body structures of lancelets. The expression patterns of a dpp-related gene, Bbbmp2/4, and two wnt-related genes, Bbwnt7 and Bbwnt8, have been studied in comparison with those of brachyury and Hnf-3 beta class genes The temporal expression patterns of these genes are similar to those of vertebrates; Bbbmp2/4 and Bbwnt8 are first expressed in the invaginating primitive gut and the equatorial region. respectively, at the initial gastrula stage. However, spatial expression pattern of Bbbmp2/4 differs significantly from the vertebrate cognates. It is expressed in the mid-dorsal inner layer of gastrulae and widely in the anterior region, in which vertebrates block BMP signaling, The present study suggests that the lancelet embryo may have two distinct developmental domains from the gastrula stage, the domains of which coincide later with the lateral diverticular and the somitocoelomic regions. The embryonic origin of the anterior-specific structures in lancelets corresponds to the anterior domain where Bbbmp2/4 is continuously expressed.; Lancelets (amphioxus), although showing the most similar anatomical features to vertebrates, never develop a vertebrate-like head but rather several structures specific to this animal. The lancelet anatomical specificity seems to be traceable to early developmental stages, such as the vertebrate dorsal and anterior-posterior determinations. The BMP and Wnt proteins play important roles in establishing the early basis of the dorsal structures and the head in vertebrates. The early behavior of BMP and Wnt may be also related to the specific body structures of lancelets. The expression patterns of a dpp-related gene, Bbbmp2/4, and two wnt-related genes, Bbwnt7 and Bbwnt8, have been studied in comparison with those of brachyury and Hnf-3 beta class genes The temporal expression patterns of these genes are similar to those of vertebrates; Bbbmp2/4 and Bbwnt8 are first expressed in the invaginating primitive gut and the equatorial region. respectively, at the initial gastrula stage. However, spatial expression pattern of Bbbmp2/4 differs significantly from the vertebrate cognates. It is expressed in the mid-dorsal inner layer of gastrulae and widely in the anterior region, in which vertebrates block BMP signaling, The present study suggests that the lancelet embryo may have two distinct developmental domains from the gastrula stage, the domains of which coincide later with the lateral diverticular and the somitocoelomic regions. The embryonic origin of the anterior-specific structures in lancelets corresponds to the anterior domain where Bbbmp2/4 is continuously expressed.
关键词	Bmp Body Plan Chordate Coelom Wnt
学科领域	Cell Biology ; Developmental Biology
收录类别	SCI
语种	英语
WOS记录号	WOS:000169756300008
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/3332
专题	实验海洋生物学重点实验室海洋环境腐蚀与生物污损重点实验室
作者单位	1.Kagoshima Univ, Sch Dent, Dept Oral Anat 1, Kagoshima 8908544, Japan 2.Kagoshima Univ, Sch Dent, Dept Oral Pathol, Kagoshima 8908544, Japan 3.Tokyo Metropolitan Univ, Dept Biol Sci, Grad Sch Sci, Tokyo 1920397, Japan 4.Chinese Acad Sci, Expt Marine Biol Lab, Inst Oceanol, Qingdao 266071, Shangdon, Peoples R China
推荐引用方式 GB/T 7714	Yasui, K,Saiga, H,Wang, Y,et al. Early expressed genes showing a dichotomous developing pattern in the lancelet embryo[J]. DEVELOPMENT GROWTH & DIFFERENTIATION,2001,43(2):185-194.
APA	Yasui, K,Saiga, H,Wang, Y,Zhang, PJ,&Semba, I.(2001).Early expressed genes showing a dichotomous developing pattern in the lancelet embryo.DEVELOPMENT GROWTH & DIFFERENTIATION,43(2),185-194.
MLA	Yasui, K,et al."Early expressed genes showing a dichotomous developing pattern in the lancelet embryo".DEVELOPMENT GROWTH & DIFFERENTIATION 43.2(2001):185-194.

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