Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Characterization of a long-chain fatty acid-CoA ligase 1 gene and association between its SNPs and growth traits in the clam Meretrix meretrix | |
Dai, Ping1,2; Huan, Pin1 ; Wang, Hongxia1; Lu, Xia2; Liu, Baozhong1
| |
| 2015-07-25 | |
| 发表期刊 | GENE
 |
| 卷号 | 566期号:2页码:194-200 |
| 文章类型 | Article |
| 摘要 | Long-chain fatty acid-CoA ligases (ACSLs) play crucial roles in fatty acid (FA) metabolism. They convert free long-chain FA into acyl-CoAs, which are key intermediates in both anabolic and catabolic pathways. A long-chain fatty acid-CoA ligase gene was cloned in the clam Meretrix meretrix (MmeACSL1), with a full-length cDNA of 1865 bp encoding 475 amino acids. Its expression was only detected in hepatopancreas by semi-quantitative reverse transcription PCR. Expression level of MmeACSL1 exhibited a significant increase in a starvation experiment (P<0.05). This indicates that MmeACSE1 plays an important role in normal metabolism of M. meretrix and may be involved in energy supply and storage. Two exon SNPs and six intron SNPs were developed in this gene by direct sequencing. A marker-trait association analysis showed that five of these SNPs were significantly associated with growth traits (P<0.05). Also, haplotypes comprised of the five SNPs were revealed to be significantly growth-related (P<0.05), which further corroborates the relationship of this gene to growth traits of M. meretrix. (C) 2015 Elsevier B.V. All rights reserved. |
| 关键词 | Acsl1 Meretrix Meretrix Starvation Growth Snps |
| DOI | 10.1016/j.gene.2015.04.047 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356189300009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/33081 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Minist Agr, Key Lab Sustainable Utilizat Marine Fisheries Res, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Ping,Huan, Pin,Wang, Hongxia,et al. Characterization of a long-chain fatty acid-CoA ligase 1 gene and association between its SNPs and growth traits in the clam Meretrix meretrix[J]. GENE,2015,566(2):194-200. |
| APA | Dai, Ping,Huan, Pin,Wang, Hongxia,Lu, Xia,&Liu, Baozhong.(2015).Characterization of a long-chain fatty acid-CoA ligase 1 gene and association between its SNPs and growth traits in the clam Meretrix meretrix.GENE,566(2),194-200. |
| MLA | Dai, Ping,et al."Characterization of a long-chain fatty acid-CoA ligase 1 gene and association between its SNPs and growth traits in the clam Meretrix meretrix".GENE 566.2(2015):194-200. |
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