Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor

doi:10.1007/s00343-010-9213-0

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	Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor
	Shi Dayong 1; Li Xiaohong 2; Li Jing1 ; Guo Shuju 1; Su Hua 1; Fan Xiao 1
	2010
发表期刊	CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
卷号	28 期号:1 页码:96-98
文章类型	Article
摘要	Thrombin, the ultimate proteinase of the coagulation cascade, is an attractive target for the treatment of a variety of cardiovascular diseases. A bromophenol derivative named (+)-3-(2,3-dibromo-4, 5-dihydroxy-phenyl)-4-bromo-5,6-dihydroxy-1,3-dihydroiso-benzofuran 1, isolated from the brown alga Leathesia nana exhibited significant thrombin inhibitory activity. In this study, we investigated the inhibition of human thrombin in vitro with this bromophenol derivative, and its antithrombotic efficacy in vivo using the arteriovenous shunt model and the ferric chloride-induced arterial thrombosis model in rats. The results show that the bromophenol derivative is a potential inhibitor of thrombin (IC(50) = 1.03 nmol/L). In antithrombotic experiments in vivo, the bromophenol derivative also shows good effect comparing with the control group. These data indicate that the bromophenol derivative is a potential drug for prophylaxis and the treatment of thrombotic diseases.
关键词	Thrombin Inhibitor Antithrombotic Effect Bromophenol Derivative
DOI	10.1007/s00343-010-9213-0
收录类别	SCI
语种	英语
WOS记录号	WOS:000275654100013
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/32889
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Qingdao Municipal Hosp, Qingdao 266011, Peoples R China
推荐引用方式 GB/T 7714	Shi Dayong,Li Xiaohong,Li Jing,et al. Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2010,28(1):96-98.
APA	Shi Dayong,Li Xiaohong,Li Jing,Guo Shuju,Su Hua,&Fan Xiao.(2010).Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,28(1),96-98.
MLA	Shi Dayong,et al."Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 28.1(2010):96-98.

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