Amphi-Eomes/Tbr1: An amphioxus cognate of vertebrate Eomesodermin and T-Brain1 genes whose expression reveals evolutionarily distinct domain in amphioxus development

doi:10.1002/jez.10149

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	Amphi-Eomes/Tbr1: An amphioxus cognate of vertebrate Eomesodermin and T-Brain1 genes whose expression reveals evolutionarily distinct domain in amphioxus development
	Satoh, G ; Takeuchi, JK ; Yasui, K ; Tagawa, K ; Saiga, H ; Zhang, PJ ; Satoh, N
	2002-08-15
发表期刊	JOURNAL OF EXPERIMENTAL ZOOLOGY
ISSN	0022-104X
卷号	294 期号:2 页码:136-145
文章类型	Article
摘要	A cDNA for a novel T-box containing gene was isolated from the amphioxus Branchiostoma belcheri. A molecular phylogenetic tree constructed from the deduced amino acid sequence of the isolated cDNA indicates that this gene belongs to the T-Brain subfamily. In situ hybridization reveals that the expression is first detected in the invaginating archenteron at the early gastrula stage and this expression is down-regulated at the neurula stage. In early larvae, the expression appears again and transcripts are detected exclusively in the pre-oral pit (wheel organ-Hatschek's pit of the adult). In contrast to the vertebrate counterparts, no transcripts are detected in the brain vesicle or nerve cord throughout the development. These results are interpreted to mean that a role of T-Brain products in vertebrate forebrain development was acquired after the amphioxus was split from the lineage leading to the vertebrates. On the other hand, comparison of the tissue-specific expression domain of T-Brain genes and other genes between amphioxus and vertebrates revealed that the pre-oral pit of amphioxus has several molecular features which are comparable to those of the vertebrate olfactory and hypophyseal placode. (C) 2002 Wiley-Liss, Inc.; A cDNA for a novel T-box containing gene was isolated from the amphioxus Branchiostoma belcheri. A molecular phylogenetic tree constructed from the deduced amino acid sequence of the isolated cDNA indicates that this gene belongs to the T-Brain subfamily. In situ hybridization reveals that the expression is first detected in the invaginating archenteron at the early gastrula stage and this expression is down-regulated at the neurula stage. In early larvae, the expression appears again and transcripts are detected exclusively in the pre-oral pit (wheel organ-Hatschek's pit of the adult). In contrast to the vertebrate counterparts, no transcripts are detected in the brain vesicle or nerve cord throughout the development. These results are interpreted to mean that a role of T-Brain products in vertebrate forebrain development was acquired after the amphioxus was split from the lineage leading to the vertebrates. On the other hand, comparison of the tissue-specific expression domain of T-Brain genes and other genes between amphioxus and vertebrates revealed that the pre-oral pit of amphioxus has several molecular features which are comparable to those of the vertebrate olfactory and hypophyseal placode. (C) 2002 Wiley-Liss, Inc.
关键词	Central-nervous-system T-box Genes Branchiostoma-belcheri Cerebral-cortex Mouse T-brain-1 Hatscheks Pit Origin Homolog Larvae Adenohypophysis
学科领域	Zoology
DOI	10.1002/jez.10149
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000177187600006
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/3284
专题	实验海洋生物学重点实验室
作者单位	1.Kyoto Univ, Grad Sch Sci, Dept Zool, Kyoto 6068502, Japan 2.Nara Inst Sci & Technol, Grad Sch Biol Sci, Nara 6300101, Japan 3.Kumamoto Univ, Inst Mol Embryol & Genet, Dept Morphogenesis, Kumamoto 860811, Japan 4.Univ Hawaii, Pacific Biomed Res Ctr, Kewalo Marine Lab, Honolulu, HI 96813 USA 5.Tokyo Metropolitan Univ, Grad Sch Sci, Dept Biol Sci, Hachioji, Tokyo 1920397, Japan 6.Chinese Acad Sci, Inst Oceanol, Expt Marine Biol Lab, Qingdao 266071, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Satoh, G,Takeuchi, JK,Yasui, K,et al. Amphi-Eomes/Tbr1: An amphioxus cognate of vertebrate Eomesodermin and T-Brain1 genes whose expression reveals evolutionarily distinct domain in amphioxus development[J]. JOURNAL OF EXPERIMENTAL ZOOLOGY,2002,294(2):136-145.
APA	Satoh, G.,Takeuchi, JK.,Yasui, K.,Tagawa, K.,Saiga, H.,...&Satoh, N.(2002).Amphi-Eomes/Tbr1: An amphioxus cognate of vertebrate Eomesodermin and T-Brain1 genes whose expression reveals evolutionarily distinct domain in amphioxus development.JOURNAL OF EXPERIMENTAL ZOOLOGY,294(2),136-145.
MLA	Satoh, G,et al."Amphi-Eomes/Tbr1: An amphioxus cognate of vertebrate Eomesodermin and T-Brain1 genes whose expression reveals evolutionarily distinct domain in amphioxus development".JOURNAL OF EXPERIMENTAL ZOOLOGY 294.2(2002):136-145.

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