Comparison of two marine sponge-associated Penicillium strains DQ25 and SC10: differences in secondary metabolites and their bioactivities

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	Comparison of two marine sponge-associated Penicillium strains DQ25 and SC10: differences in secondary metabolites and their bioactivities
	Wei, Rongbian 1,2; Li, Fuchao 3; Song, Ru 4; Qin, Song 3
	2009
发表期刊	ANNALS OF MICROBIOLOGY
ISSN	1590-4261
卷号	59 期号:3 页码:579-585
文章类型	Article
摘要	Two strains of Penicillium, DQ25 and SC10, isolated from marine sponge Haliclona angulata (Bowerbank) and Hymeniacidon sp. respectively, were subjected to stationary cultivation under GYP medium for 30 days. The fermentation extracts were undergone bioactivities assays against human pathogens, phytopathogenic fungi and brine shrimp (Artemia salina). Bioassays-guided compounds isolation was performed by Silica gel columns and Sephadex LH-20 chromatography. Spectroscopic methods were used to structures elucidation of the compounds. Results showed the activities of secondary metabolites of strain DQ25 were generally stronger than that of strain SC10. Major bioactive molecules isolated from strain DQ25 were a 1,4-naphthoquinone derivative and an unidentified alkaloid. The two components were not isolated from the extract of strain SC10. ITS sequences revealed that these two species have the greatest similarity with Penicillium vinaceum and Penicillium granulatum respectively.; Two strains of Penicillium, DQ25 and SC10, isolated from marine sponge Haliclona angulata (Bowerbank) and Hymeniacidon sp. respectively, were subjected to stationary cultivation under GYP medium for 30 days. The fermentation extracts were undergone bioactivities assays against human pathogens, phytopathogenic fungi and brine shrimp (Artemia salina). Bioassays-guided compounds isolation was performed by Silica gel columns and Sephadex LH-20 chromatography. Spectroscopic methods were used to structures elucidation of the compounds. Results showed the activities of secondary metabolites of strain DQ25 were generally stronger than that of strain SC10. Major bioactive molecules isolated from strain DQ25 were a 1,4-naphthoquinone derivative and an unidentified alkaloid. The two components were not isolated from the extract of strain SC10. ITS sequences revealed that these two species have the greatest similarity with Penicillium vinaceum and Penicillium granulatum respectively.
关键词	Symbiotic Fungi Marine Sponge Secondary Metabolites Biological Activity
学科领域	Biotechnology & Applied Microbiology ; Microbiology
收录类别	SCI
语种	英语
WOS记录号	WOS:000271346700028
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/3038
专题	实验海洋生物学重点实验室
作者单位	1.China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210018, Peoples R China 2.Zhejiang Ocean Univ, Coll Marine Sci, Zhoushan 316004, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Open Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Ocean Univ China, Coll Food Sci, Qingdao 266003, Peoples R China
推荐引用方式 GB/T 7714	Wei, Rongbian,Li, Fuchao,Song, Ru,et al. Comparison of two marine sponge-associated Penicillium strains DQ25 and SC10: differences in secondary metabolites and their bioactivities[J]. ANNALS OF MICROBIOLOGY,2009,59(3):579-585.
APA	Wei, Rongbian,Li, Fuchao,Song, Ru,&Qin, Song.(2009).Comparison of two marine sponge-associated Penicillium strains DQ25 and SC10: differences in secondary metabolites and their bioactivities.ANNALS OF MICROBIOLOGY,59(3),579-585.
MLA	Wei, Rongbian,et al."Comparison of two marine sponge-associated Penicillium strains DQ25 and SC10: differences in secondary metabolites and their bioactivities".ANNALS OF MICROBIOLOGY 59.3(2009):579-585.

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