One type of VEGFR is involved in WSSV infection to the Pacific whiteleg shrimp Litopenaeus vannamei

doi:10.1016/j.dci.2015.01.001

IOCAS-IR > 实验海洋生物学重点实验室

	One type of VEGFR is involved in WSSV infection to the Pacific whiteleg shrimp Litopenaeus vannamei
	Li, Shihao 1,2; Wang, Zhiwei1,3 ; Li, Fuhua 1,2; Xiang, Jianhai1
	2015-05-01
发表期刊	DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号	50 期号:1 页码:1-8
文章类型	Article
摘要	VEGF signaling pathway plays vital roles in many physiological processes including cell proliferation, differentiation, migration, survival, cell-cell communication, vessel permeability and virus-host interaction in mammalian species. However, the VEGF signaling pathway and its biological function are still poorly understood in crustaceans. In the present study, an essential member of VEGF signaling pathway, VEGF receptor (LvVEGFR), was isolated from Penaeid shrimp Litopenaeus vannamei and its function during virus infection was analyzed. The deduced amino acid sequence of LvVEGFR possessed all common features of VEGFRs reported in other species, including a signal peptide, six IG-like domains, one immunoglobulin subtype 2 domain, a transmembrane domain, a juxtamembrane domain, a protein kinase domain separated by a kinase insert sequence, one ATP binding site and one tyrosine-protein kinase active site. LvVEGFR is mainly expressed in hemocytes and intestine. The transcriptional level of LvVEGFR could be obviously up-regulated in hemocytes and intestine after WSSV infection. Silencing of LvVEGFR gene by double-strand RNA (dsRNA) interference could not only lead to a decrease of virus copy number in WSSV infected shrimp, but also reduce the mortality of shrimp during WSSV infection. These data suggested that VEGF signaling pathway might play an important role during viral infection to shrimp. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Vegfr Wssv Rna Interference Litopenaeus Vannamei
DOI	10.1016/j.dci.2015.01.001
收录类别	SCI
语种	英语
WOS记录号	WOS:000350931900001
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/25421
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Li, Shihao,Wang, Zhiwei,Li, Fuhua,et al. One type of VEGFR is involved in WSSV infection to the Pacific whiteleg shrimp Litopenaeus vannamei[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2015,50(1):1-8.
APA	Li, Shihao,Wang, Zhiwei,Li, Fuhua,&Xiang, Jianhai.(2015).One type of VEGFR is involved in WSSV infection to the Pacific whiteleg shrimp Litopenaeus vannamei.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,50(1),1-8.
MLA	Li, Shihao,et al."One type of VEGFR is involved in WSSV infection to the Pacific whiteleg shrimp Litopenaeus vannamei".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 50.1(2015):1-8.

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